# US 10,501,431 B2 · Selenium-enriched tea polyphenol selenide preparation

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- Number: US 10,501,431 B2
- Document ID: US10501431B2
- Status: Granted
- Kind: B2
- Application number: 14/361,301
- Filed: 2014-03-26
- Published: 2019-05-16
- Granted: 2019-12-10
- Earliest claimed: 2014-03-06
- Assignees: Shanghai Ai Qi Ecological Technology Co., Ltd.
- Applicants: Shanghai Ai Qi Ecological Technology Co., Ltd.
- Inventors: Gong Chen; Kunyuan Song
- Web page: https://patentgrep.com/patent/US10501431B2

## CPC

- C07D 311/62: with oxygen atoms directly attached in position 3, e.g. anthocyanidins
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/16: Inorganic salts, minerals or trace elements
- A23L 33/165: Complexes or chelates
- A61P 35/00: Antineoplastic agents
- A61P 37/02: Immunomodulators
- C01B 19/00: Selenium; Tellurium; Compounds thereof (phosphorus compounds C01B25/14)
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C01B: NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; {METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C}
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A selenium-enriched tea polyphenol selenide, has such a structure as wherein R1 is alkali metal ion and selenium coordination complex, and R2═H, or A method for preparing the selenium-enriched tea polyphenol selenide, comprises: A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy acid salt; and B) reacting the tea polyphenol hydroxy acid salt with SeO2, to obtain the selenium-enriched tea polyphenol selenide.

## Claims

### Claim 1

A tea polyphenol selenide, having a structure as:
wherein
or
and R2═H, or

### Claim 2 (depends on 1)

A method for preparing the tea polyphenol selenide, as recited in claim 1, comprising:
A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy salt; and
B) reacting the tea polyphenol hydroxy salt with SeO2, to obtain the tea polyphenol selenide.

### Claim 3 (depends on 2)

The method for preparing the tea polyphenol selenide, as recited in claim 2, wherein the purity of the tea polyphenol in step A) is not less than 98%.

### Claim 4 (depends on 2)

The method for preparing the tea polyphenol selenide, as recited in claim 2, wherein in step A), tea polyphenol:inorganic metallic alkali=1:0.1 to 1:0.5, a reaction temperature is 70° C. to 150° C., and a reaction time is 100 s to 250 s.

### Claim 5 (depends on 2)

The method for preparing the tea polyphenol selenide, as recited in claim 2, wherein in step B), tea polyphenol hydroxy salt: SeO2=1:0.2 to 1:0.5, a reaction temperature is 100° C. to 250° C., and a reaction time is 80 s to 300 s.

### Claim 6 (depends on 2)

The method for preparing the tea polyphenol selenide, as recited in claim 2, wherein the inorganic metallic alkali in step A) is sodium hydroxide, potassium hydroxide, or magnesium hydroxide.

### Claim 7 (depends on 1)

A method for preparing preparation of tea polyphenol selenide, as recited in claim 1, comprises:
A) reacting tea polyphenol with at least one inorganic metallic alkali, to obtain tea polyphenol hydroxy salt;
B) reacting the tea polyphenol hydroxy salt with SeO2, to obtain the tea polyphenol selenide; and
C) further preparing the tea polyphenol selenide into capsule, tablet, granules, oral liquid, or powder.

### Claim 8 (depends on 1)

A health and nutritional product, enriched food or drug, comprising the tea polyphenol selenide, as recited in claim 1.