# US 10,500,382 B2 · Drug-filled stents with filaments for increased lumen surface area and method of manufacture thereof > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,382 B2 - Document ID: US10500382B2 - Status: Granted - Kind: B2 - Application number: 15/808,610 - Filed: 2017-11-09 - Published: 2018-05-10 - Granted: 2019-12-10 - Earliest claimed: 2016-11-10 - Assignees: Medtronic Vascular, Inc. - Applicants: Medtronic Vascular, Inc. - Inventors: Ryan Bienvenu; Justin Peterson; Stefan Tunev; Michael Harms - Web page: https://patentgrep.com/patent/US10500382B2 ## CPC - A61M 31/002: {Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50)} - A61F 2/86: Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure - A61F 2/88: the wire-like elements formed as helical or spiral coils - A61L 31/022: {Metals or alloys} - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - A61L 31/18: Materials at least partially X-ray or laser opaque - A61F 2002/91541: {Adjacent bands are arranged out of phase} - A61F 2002/91575: {connected peak to trough} - A61F 2230/0006: circular - A61F 2230/0013: Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped - A61F 2240/001: Designing or manufacturing processes - A61F 2250/0051: differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts - A61F 2250/0068: the pharmaceutical product being in a reservoir - A61F 2250/0098: radio-opaque, e.g. radio-opaque markers - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract A stent including a hollow wire formed into a stent pattern. The hollow wire includes an outer member having an outer surface and an inner surface, a lumen extending longitudinally within the hollow wire, at least one opening extending from the outer surface of the outer member to the lumen, and a plurality of filaments extending longitudinally within the lumen. The plurality of filaments increases the amount of surface area available for tissue in-growth within the lumen. Each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and the spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments. ## Claims ### Claim 1 A stent comprising: a hollow wire formed into a stent pattern, wherein the hollow wire includes: an outer member having an outer surface and an inner surface; an intermediate member lining at least a portion of the inner surface of the outer member, the intermediate member having an outer surface and an inner surface; a lumen extending longitudinally within the hollow wire, wherein the lumen is defined by the inner surface of the intermediate member and extends longitudinally within the intermediate member; at least one opening disposed through the outer member to the lumen, wherein the at least one opening is disposed through the outer member and the intermediate member to the lumen; and at least one filament extending longitudinally within the lumen, wherein the at least one filament increases the amount of surface area available for tissue in-growth within the lumen. ### Claim 2 (depends on 1) The stent of claim 1, wherein the at least one filament extends a full length of the hollow wire. ### Claim 3 (depends on 1) The stent of claim 1, wherein the at least one filament has a circular cross-section. ### Claim 4 (depends on 1) The stent of claim 1, further comprising a plurality of filaments extending longitudinally within the lumen, wherein each filament of the plurality of filaments is spaced from an adjacent filament of the plurality of filaments. ### Claim 5 (depends on 4) The stent of claim 4, wherein the plurality of filaments includes at least ten filaments. ### Claim 6 (depends on 1) The stent of claim 1, wherein the outer member is formed from a cobalt-chromium alloy. ### Claim 7 (depends on 6) The stent of claim 6, wherein the at least one filament is formed from tantalum. ### Claim 8 (depends on 1) The stent of claim 1, wherein the intermediate member is formed from a radiopaque material. ### Claim 9 (depends on 1) The stent of claim 1, further comprising a biologically or pharmacologically active agent disposed in the lumen. ### Claim 10 A stent comprising: a hollow wire formed into a stent pattern, wherein the hollow wire includes: an outer member having an outer surface and an inner surface; a lumen extending longitudinally within the hollow wire; a plurality of openings, wherein each opening is disposed through the outer member to the lumen and wherein each opening of the plurality of openings is spaced from adjacent openings of the plurality of openings; and a plurality of filaments extending longitudinally within the lumen, wherein each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and wherein no material is disposed within spacing between adjacent filaments and spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments. ### Claim 11 (depends on 10) The stent of claim 10, wherein each filament of the plurality of filaments extends a full length of the hollow wire. ### Claim 12 (depends on 10) The stent of claim 10, wherein each filament of the plurality of filaments has a circular cross section. ### Claim 13 A stent comprising: a hollow wire formed into a stent pattern, wherein the hollow wire includes: an outer member having an outer surface and an inner surface; a lumen extending longitudinally within the hollow wire; at least one opening disposed through the outer member to the lumen; and a plurality of filaments extending longitudinally within the lumen, wherein each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and wherein the plurality of filaments includes at least ten filaments, and wherein spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments. ### Claim 14 (depends on 13) The stent of claim 13, wherein each filament of the plurality of filaments extends a full length of the hollow wire. ### Claim 15 (depends on 13) The stent of claim 13, wherein each filament of the plurality of filaments has a circular cross section. ### Claim 16 (depends on 13) The stent of claim 13, wherein the lumen is defined by the inner surface of the outer member and extends longitudinally within the outer member. ### Claim 17 (depends on 13) The stent of claim 13, wherein the stent further comprises: an intermediate member lining at least a portion of the inner surface of the outer member, the intermediate member having an outer surface and an inner surface, and wherein the lumen is defined by the inner surface of the intermediate member and extends longitudinally within the intermediate member, and wherein the at least one opening is disposed through the outer member and the intermediate member to the lumen. ### Claim 18 (depends on 13) The stent of claim 13, further comprising a biologically or pharmacologically active agent disposed in the lumen between adjacent filaments of the plurality of filaments. ### Claim 19 A stent comprising: a hollow wire formed into a stent pattern, wherein the hollow wire includes: an outer member having an outer surface and an inner surface; a lumen extending longitudinally within the hollow wire, wherein the lumen is defined by the inner surface of the outer member and extends longitudinally within the outer member; at least one opening disposed through the outer member to the lumen; and a plurality of filaments extending longitudinally within the lumen, wherein each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and wherein no material is disposed within spacing between adjacent filaments and the spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments.