# US 10,500,359 B2 · Method and device for therapy of periodic respiration > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,359 B2 - Document ID: US10500359B2 - Status: Granted - Kind: B2 - Application number: 14/669,741 - Filed: 2015-03-26 - Published: 2015-10-01 - Granted: 2019-12-10 - Earliest claimed: 2014-03-28 - Assignees: Loewenstein Medical Technology S.A. - Applicants: Weinmann Geraete Fuer Medizin GmbH & Co. KG - Inventors: Matthias Schwaibold; Christof Schroeter - Web page: https://patentgrep.com/patent/US10500359B2 ## CPC - A61M 16/0069: {the speed thereof being controlled by respiratory parameters, e.g. by inhalation} - A61M 16/0003: {Accessories therefor, e.g. sensors, vibrators, negative pressure} - A61M 16/024: {including calculation means, e.g. using a processor} - A61M 16/06: Respiratory or anaesthetic masks - A61M 16/16: Devices to humidify the respiration air {(A61M16/1045 takes precedence)} - A61M 16/20: Valves specially adapted to medical respiratory devices - A61M 16/0057: {Pumps therefor} - A61M 2016/0027: {pressure meter} - A61M 2016/003: {with a flowmeter} - A61M 2205/3334: Measuring or controlling the flow rate - A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient - A61M 2230/04: Heartbeat characteristics, e.g. ECG, blood pressure modulation - A61M 2230/30: Blood pressure (A61M2230/04 takes precedence) - A61M 2230/432: partial CO2 pressure (P-CO2) - A61M 2230/435: partial O2 pressure (P-O2) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract The invention relates to a method and a device for treating Cheyne-Stokes respiration, periodic respiration and central or mixed apnea. If the respiration waxes and wanes periodically, there is pressure support in phases of periodic respiration, taking into account the natural patient respiration. ## Claims ### Claim 1 A ventilator, wherein the ventilator comprises a controllable respiratory gas source for predetermining ventilation parameters in a respiratory gas supply of a patient with periodic respiration, one or more elements for establishing a measure of a current ventilation parameter of the controllable respiratory gas source, one or more first storage elements for storing a measure of a preceding ventilation parameter of the controllable respiratory gas source in a recallable manner, one or more first comparison elements for deriving a first measure of a change (increase/decrease) in a current ventilation parameter of the controllable respiratory gas source compared to a preceding ventilation parameter of the controllable respiratory gas source, one or more elements for establishing a measure of a current respiration, one or more second storage elements for storing a measure of a preceding respiration in a recallable manner, one or more second comparison elements for deriving a second measure of a change (increase/decrease) in a current respiration compared to a preceding respiration, one or more third comparison elements for deriving a third measure of a change (increase/decrease) in a respiratory exertion from at least one of the first and second measures, and a control apparatus which controls at least one ventilation parameter dependent on the third measure. ### Claim 2 (depends on 1) The ventilator of claim 1, wherein the control apparatus is configured to be capable of controlling the at least one ventilation parameter dependent on the third measure to achieve a gradient of 0 for the third measure. ### Claim 3 (depends on 1) The ventilator of claim 1, wherein the control apparatus is configured to be capable of controlling the at least one ventilation parameter dependent on the third measure to achieve a gradient of 0 for the measure of a preceding ventilation parameter. ### Claim 4 (depends on 1) The ventilator of claim 1, wherein the control apparatus controls at least an IPAP pressure and/or an EPAP pressure for a subsequent breath dependent on a change in respiratory exertion (third measure) in preceding breaths. ### Claim 5 (depends on 4) The ventilator of claim 4, wherein the control apparatus leads a pressure lift, i.e. a difference between IPAP pressure and EPAP pressure, to a preselected basal support in a step-by-step manner in phases with largely stable respiration in which respiratory exertion deviates by less than 20% from breath to breath. ### Claim 6 (depends on 1) The ventilator of claim 1, wherein pressure support is adapted on a breath-by-breath basis in case of changes in ventilation during nighttime. ### Claim 7 (depends on 1) The ventilator of claim 1, wherein recordings of at least one of a pressure curve, a flow curve, or a respiratory frequency of a natural respiration of a patient are used, at least from time to time, for modulating a pressure support. ### Claim 8 (depends on 1) The ventilator of claim 1, wherein a recording of at least one of a pressure curve, a flow curve, or a respiratory frequency of a natural respiration of a patient is used, at least from time to time, for calculating a safety frequency for the ventilation. ### Claim 9 (depends on 1) The ventilator of claim 1, wherein an expiratory positive airway pressure (EPAP) can be set from 2 to 15 cm H2O. ### Claim 10 (depends on 1) The ventilator of claim 1, wherein different pressure profiles can be applied for inspiration and expiration. ### Claim 11 (depends on 1) The ventilator of claim 1, wherein obstructions are identified by at least one of frequency-only tracking (FOT), flattening, snoring, apnea or a flow response to mandatory ventilation. ### Claim 12 (depends on 1) The ventilator of claim 1, wherein at least one of cardiac output, blood pressure, cardiac frequency, SpO2 or CO2 is established by means of an adaptable module and measured variables of the at least one of cardiac output, blood pressure, cardiac frequency, SpO2 or CO2 are used for calculating pressure support. ### Claim 13 (depends on 1) The ventilator of claim 1, wherein control of a power of a humidifier connected to the ventilator is carried out dependent on a measure of pressure support. ### Claim 14 (depends on 1) The ventilator of claim 1, wherein during an initial accustoming phase a pressure support that is lower than an ideal calculated one is applied. ### Claim 15 (depends on 1) A method for controlling the respiratory gas supply of a patient with periodic respiration using the apparatus of claim 1, wherein the method comprises: establishing a measure of a current ventilation parameter, storing, in a recallable fashion, a measure of a preceding ventilation parameter, establishing a first measure of a change (increase/decrease) in a current ventilation parameter compared to a preceding ventilation parameter, establishing a measure of a current respiration, storing, in a recallable fashion, a measure of a preceding respiration, establishing a second measure for a change (increase/decrease) in a current respiration compared to a preceding respiration, establishing a third measure for a change (increase/decrease) in a respiratory exertion from at least one of the first and second measures, controlling at least one ventilation parameter dependent on the third measure.