# US 10,500,345 B2 · Spring assisted drug delivery device

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- Number: US 10,500,345 B2
- Document ID: US10500345B2
- Status: Granted
- Kind: B2
- Application number: 15/034,497
- Filed: 2014-11-17
- Published: 2016-09-29
- Granted: 2019-12-10
- Earliest claimed: 2013-11-22
- Assignees: Sanofi-Aventis Deutschland GmbH
- Applicants: Sanofi-Aventis Deutschland GmbH
- Inventors: Stefan Blancke; Axel Teucher; Michael Jugl; Christiane Schneider
- Web page: https://patentgrep.com/patent/US10500345B2

## CPC

- A61M 5/31551: {including axial movement of dose setting member}
- A61M 5/3146: {Priming, e.g. purging, reducing backlash or clearance}
- A61M 5/3155: {by rotational movement of dose setting member, e.g. during setting or filling of a syringe}
- A61M 5/31566: {Means improving security or handling thereof}
- A61M 5/31578: {the piston rod being moved by the axial movement of a component directly in contact with it}
- A61M 5/3158: {the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button}
- A61M 5/31585: {the component being manually operated or triggered by an axially moving actuator operated by user, e.g. an axially movable injection button}
- A61M 5/31593: {Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir}
- A61M 5/31558: {using scaling up or down transmissions, e.g. gearbox}
- A61M 5/31561: {using freely adjustable volume steps}
- A61M 5/31575: {using scaling up or down transmissions, e.g. gearbox}
- A61M 2005/3126: {related to dosing}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A spring assisted drug delivery device is provided comprising a housing and a lead screw having a longitudinal axis, a distal end and a proximal end that is rotatably fixed during dose setting and dose delivery and axially movable in a distal direction relative to the housing. The device further comprises a drive nut threadedly engaged and screwable along the lead screw threaded shaft and a number sleeve threadedly engaged with the housing to be screwable relative to the housing. A dial link is connected with the drive nut and axially movable and rotatably fixed relative to the drive nut and an inner sleeve is threadedly engaged with the number sleeve, the inner sleeve being axially movable and rotatably fixed relative to the housing. A mid-body is axially fixed inside of the housing. A spring is provided that assists a user of the device during a dose administration step.

## Claims

### Claim 1

A spring assisted drug delivery device comprising:
a housing,
a lead screw that is rotatably fixed with respect to the housing during dose setting and during dose delivery and that is axially moveable in a delivery direction relative to the housing for dose delivery,
a drive mechanism adapted and arranged to drive the lead screw in the delivery direction for dose delivery, and
a spring, wherein the spring is arranged between two components of the drive mechanism which are moveable with respect to one another and wherein the spring is adapted and arranged to assist a user of the spring assisted drug delivery device while the user applies a force to drive the lead screw during a dose delivery operation such that the force the user must exert for performing the delivery operation is reduced.

### Claim 2 (depends on 1)

The spring assisted drug delivery device according to claim 1, wherein the spring is adapted and arranged to be tensioned during dose setting and, wherein, during dose delivery, the tension of the spring is reduced.

### Claim 3 (depends on 1)

The spring assisted drug delivery device according to claim 1, wherein the spring assisted drug delivery device further comprises a cartridge comprising a piston, wherein, for dose delivery, the piston is moveable with respect to the cartridge in the delivery direction by the lead screw, and wherein the components of the drive mechanism comprise
an inner sleeve which is axially moveable and rotatably fixed relative to the housing,
a mid-body which is axially fixed inside of the housing,
a drive nut, wherein the lead screw comprises a threaded shaft, wherein the drive nut is threadedly engaged with the threaded shaft, and wherein, for dose delivery, the drive nut is adapted to advance the lead screw with respect to the housing to dispense a fluid from the cartridge,
a dial link which is connected with the drive nut, wherein the dial link is axially moveable with respect to the drive nut and rotatably fixed relative to the drive nut, and
a number sleeve which is threadedly engaged with the housing.

### Claim 4 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the lead screw comprises a keyway arranged along the threaded shaft, and wherein the mid-body comprises tabs that slidably fit within the keyway in the lead screw to prevent rotation of the lead screw with respect to the housing.

### Claim 5 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the inner sleeve is axially moveable and rotatably fixed relative to the mid-body by means of at least one lug of the mid-body that slidably fits within at least one slot formed in the inner sleeve.

### Claim 6 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the dial link is rotatably fixed with respect to the number sleeve for dose setting, and wherein the number sleeve is rotatable relative to the dial link during dose delivery.

### Claim 7 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the number sleeve comprises a threading for threaded engagement with the housing, the threading of the number sleeve for threaded engagement with the housing being of a first lead, and wherein the number sleeve comprises a threading for threaded engagement with the inner sleeve, the threading of the inner sleeve for threaded engagement with the number sleeve being of a second lead, and wherein the lead screw comprises a threading, the threading of the lead screw being of a third lead, wherein the first lead, the second lead and the third lead are different from one another.

### Claim 8 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein during dose setting, the dial link and the number sleeve are in a first axial arrangement, whereby a screwing motion of the dial link and the number sleeve relative to the housing is adapted to screw the dial link and the number sleeve a first axial distance away from a home position with respect to the housing, which screwing motion of the dial link is configured to screw the drive nut along the lead screw for a second axial distance that is different from the first axial distance, and wherein during dose delivery, the dial link and the number sleeve are in a second axial arrangement, whereby a screwing motion of the number sleeve relative to the housing back towards the home position is adapted to advance the inner sleeve without rotation in the delivery direction to axially advance the drive nut and, thus, the lead screw and the piston to dispense fluid from the cartridge.

### Claim 9 (depends on 8)

The spring assisted drug delivery device according to claim 8, wherein the first axial distance the number sleeve is moved with respect to the housing for dose setting is equal to the first axial distance the dial link is moved with respect to the housing for dose setting.

### Claim 10 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the spring is operatively coupled between the mid-body and the inner sleeve and wherein, for dose setting, the inner sleeve is adapted to be axially moved relative to the housing and to the mid-body such that tension is created in the spring.

### Claim 11 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the spring is operatively coupled between the dial link and the drive nut, and
wherein, for dose setting, the dial link is adapted to be screwed with respect to the housing in a direction opposite to the delivery direction for a first axial distance and the drive nut is adapted to be screwed with respect to the housing in the direction opposite to the delivery direction for a second axial distance, the second axial distance being smaller than the first axial distance, such that tension is created in the spring.

### Claim 12 (depends on 3)

The spring assisted drug delivery device according to claim 3, wherein the number sleeve is rotatable and axially moveable with respect to the housing for dose setting and for dose delivery, and wherein the spring is operatively coupled between the number sleeve and the inner sleeve, wherein for dose setting, the number sleeve is adapted to be screwed with respect to the housing and with respect to the inner sleeve in a direction opposite to the delivery direction for a first axial distance and the inner sleeve is adapted to be moved with respect to the housing in the direction opposite to the delivery direction for a second axial distance, the second axial distance being smaller than the first axial distance, such that tension is created in the spring.

### Claim 13 (depends on 1)

The spring assisted drug delivery device according to claim 1, wherein the spring comprises a pre-loaded spring.

### Claim 14 (depends on 1)

The spring assisted drug delivery device according to claim 1, wherein the spring comprises a tension spring.

### Claim 15 (depends on 1)

The spring assisted drug delivery device according to claim 1, wherein the spring comprises a torsion spring.