# US 10,500,335 B2 · Medicament delivery device sub-assembly > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,335 B2 - Document ID: US10500335B2 - Status: Granted - Kind: B2 - Application number: 15/033,133 - Filed: 2014-11-03 - Published: 2016-09-15 - Granted: 2019-12-10 - Earliest claimed: 2013-11-01 - Assignees: Consort Medical PLC - Applicants: Consort Medical PLC - Inventors: Rachel Koppelman; Alan Judd; Alastair Willoughby - Web page: https://patentgrep.com/patent/US10500335B2 ## CPC - A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence) - A61M 5/2053: {Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155)} - A61M 5/3148: {Means for causing or aiding aspiration or plunger retraction} - A61M 5/3204: {Needle cap removers, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices} - A61M 5/326: {Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user} - A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)} - A61M 5/46: having means for controlling depth of insertion - A61M 2005/2026: {Semi-automatic, e.g. user activated piston is assisted by additional source of energy} - A61M 2005/3247: {Means to impede repositioning of protection sleeve from needle covering to needle uncovering position} - A61M 2005/3267: {Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body} - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A sub-assembly for a medicament delivery device including a housing, a propellant source contained in and axially moveable relative to said housing, and a button axially moveable relative to said housing. At least part of said button is disposed axially rearwardly of part of said propellant source. The button includes one or more radially flexible blocking members, and the button is moveable between a first axial position in which the one or more radially flexible blocking members are radially restrained by the housing in a radially inward position that limits rearward axial movement of the propellant source, and a second axial position in which the one or more radially flexible blocking members are able to flex to a radially outward position and permit rearward axial movement of the propellant source relative to the button and the housing. ## Claims ### Claim 1 A sub-assembly for a medicament delivery device, the sub-assembly comprising: a housing; a propellant source contained in and axially moveable relative to said housing; and a button axially moveable relative to said housing, at least a part of said button being disposed axially rearwardly of a part of said propellant source; wherein the button includes one or more radially flexible blocking members, and the button is moveable between a first axial position in which the one or more radially flexible blocking members are radially restrained by the housing in a radially inward position that limits rearward axial movement of the propellant source, and a second axial position in which the one or more radially flexible blocking members are movable from the radially inward position to a radially outward position by a rearwardly axial force acting on the one or more radially flexible blocking members and permit rearward axial movement of the propellant source relative to the button and the housing; wherein the rearwardly axial force is created by a vapor pressure following release of a propellant from the propellant source. ### Claim 2 (depends on 1) The sub-assembly according to claim 1, wherein the one or more radially flexible blocking members have a tapered front surface such that the one or more radially flexible blocking members are moveable from the radially inward position to the radially outward position by the rearwardly axial force acting on the tapered front surface when in the second axial position. ### Claim 3 (depends on 1) The sub-assembly according to claim 1, wherein the housing includes a rear housing and a front housing, and axially rearward movement of the propellant source relative to the housing causes a retraction biasing member to delatch, wherein the delatched retraction biasing member urges the rear housing axially rearwardly relative to the front housing. ### Claim 4 (depends on 3) The sub-assembly according to claim 3, wherein the retraction biasing member is delatched when latch heads are moved from a radially inward position to a radially outward position. ### Claim 5 (depends on 4) The sub-assembly according to claim 4, wherein the axially rearward movement of the propellant source relative to the housing permits axially rearward movement of a plug, wherein axially rearward movement of the plug urges the latch heads from the radially inward position to the radially outward position. ### Claim 6 (depends on 5) The sub-assembly according to claim 5, wherein the latch heads are disposed on radially flexible legs, and wherein the plug includes hooks that are engageable with the radially flexible legs so as to prevent the radially flexible legs from flexing radially outwardly, the hooks being capable of disengaging the radially flexible legs when the plug moves axially rearwardly relative to the radially flexible legs. ### Claim 7 (depends on 4) The sub-assembly according to claim 4, wherein the latch heads are formed on an inner housing and the latch heads are axially aligned with first stops of the front housing when in the radially outward position, and wherein abutment between the latch heads and first stops prevents axially rearward movement of the inner housing relative to the front housing. ### Claim 8 (depends on 3) The sub-assembly according to claim 3, wherein one of the front housing and rear housing includes second stops and the other of the front housing and rear housing includes lock out elements, wherein engagement between the second stops and lock out elements prevents forwardly and rearwardly axial movement of the rear housing relative to the front housing, and wherein the second stops are engageable in the lock out elements when the rear housing is axially rearwardly displaced relative to the front housing by a predetermined axial distance. ### Claim 9 (depends on 1) The sub-assembly according to claim 1, further comprising one or more latches on one of the button or the housing, wherein the one or more latches engage the other of the button or the housing when the button is in the second axial position, and wherein engagement of the one or more latches prevents axially rearward movement of the button relative to the housing. ### Claim 10 (depends on 1) The sub-assembly according to claim 1, further comprising a needle sleeve wherein the needle sleeve is axially moveable relative to the housing between a forward axial position and a rearward axial position, wherein in the rearward axial position the needle sleeve determines maximum axial length of a needle extending therethrough relative to the needle sleeve. ### Claim 11 (depends on 10) The sub-assembly according to claim 10, further including a biasing member that biases the needle sleeve towards the forward axial position relative to the housing. ### Claim 12 (depends on 1) The sub-assembly according to claim 1, wherein a forward surface of the sub-assembly is inclined relative to a longitudinal axis of the sub-assembly, wherein an angle of inclination of the forward surface determines an angle at which the sub-assembly may be held against a delivery site to achieve maximum penetration of a needle extending from the sub-assembly. ### Claim 13 (depends on 1) The sub-assembly according to claim 1, wherein the sub-assembly includes a series of points that are each an axially most forward point of the sub-assembly at a given radii, and wherein the series of points lie in a plane that is inclined relative to a longitudinal axis of the sub-assembly, wherein an angle of inclination of the plane determines a minimum angle at which a needle of a syringe mounted in the sub-assembly may be inserted into a delivery site. ### Claim 14 (depends on 1) The sub-assembly according to claim 1, were the propellant source comprises a reservoir housing defining a reservoir for containing the propellant, and a stem having a bore therethrough, at least one inlet in fluid communication with the bore, and an open outlet end in fluid communication with the bore, the stem being moveable relative to the reservoir housing between a first position in which the at least one inlet is not in fluid communication with the reservoir and a second position in which the at least one inlet is in fluid communication with the bore. ### Claim 15 (depends on 14) The sub-assembly according to claim 14, wherein the propellant source further comprising a biasing member for biasing the stem towards the first position. ### Claim 16 (depends on 14) The sub-assembly according to claim 14, wherein the reservoir contains a liquefied gas propellant. ### Claim 17 (depends on 14) The sub-assembly according to claim 14, wherein the reservoir contains the propellant that is or contains a hydrofluoroalkane (HFA). ### Claim 18 (depends on 17) The sub-assembly according to claim 17, wherein the propellant is or contains HFA134a. ### Claim 19 A medicament delivery device comprising: a sub-assembly comprising: a housing; a propellant source contained in and axially moveable relative to said housing; and a button axially moveable relative to said housing, at least a part of said button being disposed axially rearwardly of a part of said propellant source; wherein the button includes one or more radially flexible blocking members, and the button is moveable between a first axial position in which the one or more radially flexible blocking members are radially restrained by the housing in a radially inward position that limits rearward axial movement of the propellant source, and a second axial position in which the one or more radially flexible blocking members are movable from the radially inward position to a radially outward position by a rearwardly axial force acting on the one or more radially flexible blocking members and permit rearward axial movement of the propellant source relative to the button and the housing; wherein the rearwardly axial force is created by a vapor pressure following release of a propellant from the propellant source; and a syringe connected to the sub-assembly, wherein the syringe includes a barrel for containing a medicament, the barrel having an outlet at a front end, and a stopper axially moveable in the barrel. ### Claim 20 (depends on 19) The medicament delivery device according to claim 19 wherein the syringe further includes a needle in fluid communication with the outlet. ### Claim 21 (depends on 19) The medicament delivery device according to claim 19, wherein: the housing includes a rear housing and a front housing, and axially rearward movement of the propellant source relative to the housing causes a retraction biasing member to delatch, wherein the delatched retraction biasing member urges the rear housing axially rearwardly relative to the front housing; and the syringe is axially restrained relative to the rear housing such that axial movement of the rear housing relative to the front housing causes axial movement of the syringe relative to the front housing. ### Claim 22 A sub-assembly for a medicament delivery device, the sub-assembly comprising: a housing; a propellant source contained in and axially moveable relative to said housing; and a button axially moveable relative to said housing, at least a part of said button being disposed axially rearwardly of a part of said propellant source; wherein the button includes one or more radially flexible blocking members, and the button is moveable between a first axial position in which the one or more radially flexible blocking members are radially restrained by the housing in a radially inward position that limits rearward axial movement of the propellant source, and a second axial position in which the one or more radially flexible blocking members are able to flex to a radially outward position and permit rearward axial movement of the propellant source relative to the button and the housing; wherein the housing includes a rear housing and a front housing, and axially rearward movement of the propellant source relative to the housing causes a retraction biasing member to delatch, wherein the delatched retraction biasing member urges the rear housing axially rearwardly relative to the front housing; wherein the retraction biasing member is delatched when latch heads are moved from a radially inward position to a radially outward position.