# US 10,500,325 B2 · Wearable filtrating artificial kidney device

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- Number: US 10,500,325 B2
- Document ID: US10500325B2
- Status: Granted
- Kind: B2
- Application number: 15/521,621
- Filed: 2016-09-23
- Published: 2019-04-04
- Granted: 2019-12-10
- Earliest claimed: 2016-09-23
- Applicants: Sichuan University
- Inventors: Changsheng Zhao; Baihai Su; Weifeng Zhao; Shudong Sun; Chen Wang; Zhenqiang Shi; Qiang Liu; Xiaohua Zhang; Ping Fu; Jianhui Zhou
- Web page: https://patentgrep.com/patent/US10500325B2

## CPC

- A61M 1/1621: {Constructional aspects thereof (semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00)}
- A61M 1/1654: {Dialysates therefor}
- A61M 1/30: Single needle dialysis {; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis}
- A61M 1/34: Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M 1/3672: {Means preventing coagulation}
- A61M 1/3679: {by absorption (A61M1/3675 takes precedence)}
- A61M 2202/0413: Blood
- A61M 2205/3355: Controlling downstream pump pressure
- A61M 2209/088: on the body
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

A wearable filtrating artificial kidney device, comprising a transfusion inlet (2), a blood pump (3), an arterial pressure detector (4), a blood filter (7), a venous pressure detector (8) and an air detector (9), wherein the transfusion inlet (2), the blood pump (3), the arterial pressure detector (4), a resin hemoperfusion apparatus (5), an active carbon hemoperfusion apparatus (6), the blood filter (7), the venous pressure detector (8) and the air detector (9) are connected sequentially; a liquid waste outlet of the blood filter (7) is connected with an ultrafiltration control pump (10). Glomerulus filtration can be simulated to achieve the goal of removing toxins and excessive moisture in the blood by virtue of ultrafiltration of the blood filter (7). A dialyzate and a complicated dialyzate circulating device are not used for the device, so that the volume and weight of the device can be reduced greatly, and the device can be worn conveniently. The device is simple in structure, easy in operation and low in cost.

## Claims

### Claim 1

A wearable filtrating artificial kidney device, comprising a blood pipeline, wherein the blood pipeline is sequentially provided with a blood inlet switch (1), a transfusion inlet (2), a blood pump (3), an arterial pressure detector (4), a blood filter (7), a venous pressure detector (8), an air detector (9), and a blood outlet switch (12) in a blood flowing direction;
the blood filter (7) includes an inlet, an outlet and a liquid waste outlet, the inlet and the outlet are connected with the blood pipeline, the liquid waste outlet is connected with a liquid waste pipeline on which an ultrafiltration control pump (10) and a liquid waste switch (11) are arranged,
the arterial pressure detector (4) and the venous pressure detector (8) are respectively used for detecting the pressure at an inlet end and an outlet end of the blood filter (7), and the air detector (9) is used for detecting the amount of bubbles in the returned blood;
a resin hemoperfusion apparatus (5) and an active carbon hemoperfusion apparatus (6) are arranged between the arterial pressure detector (4) and the blood filter (7);
the resin hemoperfusion apparatus (5) is internally provided with a urease resin microsphere adsorbent and a β2-microglobulin adsorbent.

### Claim 2 (depends on 1)

The wearable flit rating artificial kidney device according to claim 1, wherein the active carbon hemoperfusion apparatus (6) is internally provided with a membrane coated activated carbon adsorbent and/or an endotoxin adsorbent.

### Claim 3 (depends on 1)

The wearable filtrating artificial kidney device according to claim 1, wherein the arterial pressure detector (4), the venous pressure detector (8) and the air detector (9) are all provided with alarm units that give an alarm respectively while monitoring the data exceeds a preset threshold, and all detectors are connected with a display.