# US 10,500,323 B2 · Systems and methods for fluid flows and/or pressures for circulation and perfusion enhancement > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,323 B2 - Document ID: US10500323B2 - Status: Granted - Kind: B2 - Application number: 15/397,412 - Filed: 2017-01-03 - Published: 2017-04-27 - Granted: 2019-12-10 - Earliest claimed: 2012-03-26 - Assignees: Procyrion, Inc. - Applicants: Procyrion, Inc. - Inventors: Jason J. Heuring; William L. Clifton; Benjamin A. Hertzog; Michael P. Cuchiara; Reynolds M. Delgado, III - Web page: https://patentgrep.com/patent/US10500323B2 ## CPC - A61M 60/237: the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps - A61M 60/50: Details relating to control - A61M 60/216: including a rotating member acting on the blood, e.g. impeller - A61M 60/33: of kidneys - A61M 60/408: the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable - A61M 60/416: transmitted directly by the motor rotor drive shaft - A61M 60/577: High-frequency driving - A61M 60/812: Vanes or blades, e.g. static flow guides - A61M 60/857: Implantable blood tubes - A61M 60/861: Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient's body - A61M 60/139: inside the aorta, e.g. intra-aortic balloon pumps - A61M 60/148: in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices - A61M 60/414: transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter - A61M 60/894: Passive valves, i.e. valves actuated by the blood - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Fluid pressure or flow in a human body may be adjusted with circulation or perfusion systems and methods. The system may include a first pump implantable in a chamber or vessel of the human body, and a plurality of struts connected to a housing of the first pump, wherein the struts secure the first pump in a desired location of the chamber or vessel. The system may also include one or more flow modification elements disposed on the first pump, where the flow modification elements direct flow to a desired organ or a desired vessel to adjust pressure or flow as desired. ## Claims ### Claim 1 A method for adjusting fluid flow or pressure within a human body, the method comprising: transluminally inserting a pumping system for percutaneous delivery in a desired chamber or a desired vessel of the human body, wherein the pumping system comprises a first pump implantable in a chamber or vessel of the human body, a securing means extending from said first pump, wherein said securing means secures the first pump in a desired location of said chamber or vessel, and the securing means allows substantially unobstructed flow of blood around the first pump, one or more inlet ports disposed on said first pump, wherein said inlet ports direct inlet blood flow through the first pump, and bypass flow is directed around a pump housing, and one or more outlet ports disposed on said first pump, wherein said outlet ports direct at least one high-velocity jet of output blood flow from the first pump, and the output blood flow autoentrains the bypass flow to form downstream blood flow, wherein the one or more outlet ports comprise an inducement nozzle that draws the bypass flow into the center of a lumen, and the at least one high-velocity jet consists of a plurality of jets positioned around the center of the lumen; deploying said securing means to secure said pumping system in a lumen of said desired chamber or said desired vessel, wherein the pumping system is deployed in a descending thoracic aorta superior to the celiac, renal, and mesenteric arteries, and the pumping system produces a pressure drop in an aortic root, reduces cardiac afterload, and increases cardiac output; and operating the pumping system to cause the at least one high-velocity jet of the output blood flow to autoentrain the bypass blood flow. ### Claim 2 (depends on 1) The method of claim 1, further comprising deploying said outlet ports to direct flow to a desire organ or a desired region. ### Claim 3 (depends on 1) The method of claim 1, wherein the outlet ports are oriented to increase pressure or flow to at least one renal artery. ### Claim 4 (depends on 3) The method of claim 3, further comprising a second pump positioned to pump in a direction opposite a pumping direction of the first pump. ### Claim 5 (depends on 4) The method of claim 4, wherein a first outlet of the first pump and a second outlet of the second pump face towards each other. ### Claim 6 (depends on 3) The method of claim 3, wherein the one or more outlet ports of the first pump comprise a first outlet port directing a portion of the output blood flow to a first renal artery, and a second outlet port directing another portion of the output blood flow to a second renal artery. ### Claim 7 (depends on 1) The method of claim 1, wherein the outlet ports are positioned to increase or decrease pressure in a desired region. ### Claim 8 (depends on 1) The method of claim 1, wherein the pumping system is deployed above aortic bifurcation. ### Claim 9 (depends on 1) The method of claim 1, wherein the pumping system is oriented to adjust flow or pressure to one or more branching vessels. ### Claim 10 (depends on 1) The method of claim 1, wherein the pumping system increases pressure in the abdominal aorta. ### Claim 11 (depends on 1) The method of claim 1, wherein the pumping system minimizes reverse bypass flow. ### Claim 12 (depends on 1) The method of claim 1, wherein the pumping system increases both pressure and flow downstream to key end organs. ### Claim 13 (depends on 1) The method of claim 1, wherein the pumping system maintains pulsatility. ### Claim 14 (depends on 1) The method of claim 1, wherein the pumping system enhances kidney perfusion. ### Claim 15 (depends on 1) The method of claim 1, wherein the first pump is deployed in the descending thoracic aorta near a diaphragm for downward flow, and the one or more outlet ports are configured to produce swirl. ### Claim 16 (depends on 1) The method of claim 1, wherein the first pump is deployed just above an aortic bifurcation to produce upward flow that is opposite native flow. ### Claim 17 (depends on 1) The method of claim 1, further comprising removing the first pump and the securing means when therapy is complete. ### Claim 18 A method for adjusting fluid flow or pressure within a human body, the method comprising: transluminally inserting a pumping system for percutaneous delivery in a desired chamber or a desired vessel of the human body, wherein the pumping system comprises a first pump implantable in a chamber or vessel of the human body, a securing means extending from said first pump, wherein said securing means secures the first pump in a desired location of said chamber or vessel, and the securing means allows substantially unobstructed flow of blood around the first pump, one or more inlet ports disposed on said first pump, wherein said inlet ports direct inlet blood flow through the first pump, and bypass flow is directed around a pump housing, and one or more outlet ports disposed on said first pump, wherein said outlet ports direct at least one high-velocity jet of output blood flow from the first pump, and the output blood flow autoentrains the bypass blood flow to form downstream blood flow; deploying said securing means to secure said pumping system in a lumen of said desired chamber or said desired vessel, wherein the pumping system is deployed in a descending thoracic aorta superior to the celiac, renal, and mesenteric arteries, and the pumping system produces a pressure drop in an aortic root, reduces cardiac afterload, and increases cardiac output, wherein further the outlet ports are oriented to increase pressure or flow to at least one renal artery, and the one or more outlet ports of the first pump comprise a first outlet port directing a portion of the output blood flow to a first renal artery, and a second outlet port directing another portion of the output blood flow to a second renal artery; and operating the pumping system to cause the at least one high-velocity jet of the output blood flow to autoentrain the bypass blood flow. ### Claim 19 (depends on 18) The method of claim 18, wherein the pumping system maintains pulsatility.