# US 10,500,314 B2 · Flexible substrate/liquid electrolyte viscous composite material and preparation method therefor

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- Number: US 10,500,314 B2
- Document ID: US10500314B2
- Status: Granted
- Kind: B2
- Application number: 15/777,203
- Filed: 2016-04-26
- Published: 2018-11-22
- Granted: 2019-12-10
- Earliest claimed: 2016-04-15
- Assignees: Soochow University
- Applicants: Soochow University
- Inventors: Lei Yang; Ning Sun; Xiao Lin; Wei Jiang; Xinhong Wang; Yanjie Bai; Huilin Yang; Aobing Bai
- Web page: https://patentgrep.com/patent/US10500314B2

## CPC

- A61L 27/58: Materials at least partially resorbable by the body
- A61L 27/047: {Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06}
- A61L 27/20: Polysaccharides
- A61L 27/222: {Gelatin}
- A61L 27/446: {with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46}
- A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 2430/20: for reconstruction of the heart, e.g. heart valves
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Disclosed is a flexible substrate/liquid electrolyte viscous composite material and preparation method therefor. The preparation method includes: adding a particular percentage by weight of a flexible substrate to a liquid electrolyte solution having a particular concentrate; fully stirring the solution at a particular temperature to dissolve and evenly disperse the substrate, so as to obtain a viscous liquid; and then standing the viscous liquid at a particular temperature for a particular period of time to obtain the material. The material has viscosity due to which the material can actively adhere to the surface of tissue of an organ, the mechanical property matching cardiac muscle, biocompatibility and security, and is used for treating acute and chronic myocardial infarction and heart failures, inhibiting the reconstruction, thinning, and fiberization of a ventricular wall, and improving the myocardial function. In addition, the material also features conductivity, in vivo degradability, and the like.

## Claims

### Claim 1

A flexible substrate/liquid electrolyte viscous composite biomedical material for the treatment of myocardium infarction and heart failure, consisting of:
a flexible substrate selected from the group consisting of and corn starch; and
a liquid electrolyte is a solution containing one selected from the group consisting of zinc nitrate, lithium nitrate, calcium nitrate, magnesium nitrate, potassium nitrate, lithium chloride, calcium chloride, zinc chloride, magnesium chloride, calcium iodine, and a combination thereof,
wherein the material's bonding strength with the surface of organ tissue is higher than 0.1 Kpa, and the ratio of loss modulus to storage modulus of said material is 0.2 to 5 when tested at 37° C., oscillation frequency at 0.01 to 100 Hz, strain at 0.01 to 10; at 37° C., the elastic tensile strength of said material is 3 to 100 kPa, and the elongation to fracture is more than 50%, the time for reaching the 10% stress relaxation rate is less than 10 min; at 37° C., the electric conductivity is between 0.01 and 10 S/m, the cytotoxicity level of material extract is 0 to 1; and
wherein the flexible substrate/liquid electrolyte viscous composite biomedical material is adapted for the treatment of myocardium infarction and heart failure.

### Claim 2 (depends on 1)

A preparation method of the flexible substrate/liquid electrolyte viscous composite material according to claim 1, comprising the following steps:
(1) according to the mass percent of 10% to 20%, dissolving the metallic salt into deionized water to form an electrolyte solution;
(2) according to the mass percent of 3% to 10%, mixing flexible substrate into the electrolyte solution prepared in step (1), then stirring at the temperature between 25 and 80° C. to form a viscous liquid;
(3) aging the viscous liquid obtained in step (2) between 25 and 45° C. until the material achieving a stable state, to obtain the flexible substrate/liquid electrolyte viscous composite material.

### Claim 3 (depends on 2)

The preparation method of the flexible substrate/liquid electrolyte viscous composite material according to claim 2, wherein said metallic salt is either of zinc nitrate, lithium nitrate, calcium nitrate, magnesium nitrate, potassium nitrate, lithium chloride, calcium chloride, zinc chloride, magnesium chloride, calcium iodine or any combination thereof.