# US 10,500,312 B2 · Bioactive porous bone graft compositions with collagen

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,500,312 B2
- Document ID: US10500312B2
- Status: Granted
- Kind: B2
- Application number: 14/543,862
- Filed: 2014-11-17
- Published: 2015-03-12
- Granted: 2019-12-10
- Earliest claimed: 2013-03-14
- Assignees: Prosidyan, Inc.
- Applicants: Prosidyan, Inc.
- Inventors: Charanpreet S. Bagga; Steve B. Jung; Hyun W. Bae
- Web page: https://patentgrep.com/patent/US10500312B2

## CPC

- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/34: Macromolecular materials
- A61L 27/446: {with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 2300/10: containing or releasing inorganic materials
- A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L 2300/104: Silver, e.g. silver sulfadiazine
- A61L 2300/112: Phosphorus-containing compounds, e.g. phosphates, phosphonates
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/412: Tissue-regenerating or healing or proliferative agents
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.

## Claims

### Claim 1

A porous, composite bone graft implant, comprising:
a first component comprising a bioactive glass material in the form of a plurality of porous fibrous clusters, each cluster comprising a matrix of randomly oriented bioactive glass fibers and first bioactive glass granules, and each cluster including a bioactive glass shell at least partially encasing each cluster, wherein the size of each cluster is about 0.75 mm to about 4 mm;
a second component comprising a plurality of second bioactive glass granules, wherein the size of each second bioactive glass granule is about 50 μm to about 450 μm; and
a third component comprising a collagen material for incorporation with the first and second components;
each of the components having a different resorption rate than the other component;
wherein the composite implant comprises a pore size distribution including pores characterized by pore diameters ranging from about 100 nanometer to about 1 millimeter, and wherein the composite implant is pliable.

### Claim 2 (depends on 1)

The implant of claim 1, wherein the bioactive glass material is selected from the group consisting of sol gel derived bioactive glass, melt derived bioactive glass, silica based bioactive glass, silica free bioactive glass, phosphate based bioactive glass, crystallized bioactive glass, and bioactive glass containing trace elements.

### Claim 3 (depends on 1)

The implant of claim 1, wherein the bioactive glass material comprises a partially crystallized or fully crystallized bioactive glass.

### Claim 4 (depends on 1)

The implant of claim 1, wherein the collagen material is selected from the group consisting of a human-derived collagen, animal-derived collagen, and combination of both.

### Claim 5 (depends on 4)

The implant of claim 4, wherein the collagen material is fully or partially soluble.

### Claim 6 (depends on 4)

The implant of claim 4, wherein the collagen material comprises fibrous collagen.

### Claim 7 (depends on 1)

The implant of claim 1, wherein the collagen material is porous.

### Claim 8 (depends on 1)

The implant of claim 1, further including a calcium salt selected from the group consisting of tricalcium phosphate, hydroxyapatite, calcium carbonate, calcium hydroxide, and calcium sulfate.

### Claim 9 (depends on 1)

The implant of claim 1, further including a trace element.

### Claim 10 (depends on 1)

The implant of claim 1, further being in the form of a conformable putty.

### Claim 11 (depends on 1)

The implant of claim 1, further being in the form of a conformable foam.

### Claim 12 (depends on 1)

The implant of claim 1, further being in the form of a strip.

### Claim 13 (depends on 1)

The implant of claim 1, further being injectable into a target site.

### Claim 14 (depends on 1)

The implant of claim 1, wherein the bioactive glass shell is partially or fully sintered.

### Claim 15 (depends on 1)

The implant of claim 1, wherein the bioactive glass shell is porous.

### Claim 16 (depends on 1)

The implant of claim 1, wherein at least some of the plurality of fibrous clusters are partially or fully sintered.