# US 10,500,310 B2 · Scaffold

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- Number: US 10,500,310 B2
- Document ID: US10500310B2
- Status: Granted
- Kind: B2
- Application number: 15/026,830
- Filed: 2014-10-02
- Published: 2016-08-11
- Granted: 2019-12-10
- Earliest claimed: 2013-10-04
- Assignees: Oxford University Innovation Limited
- Applicants: Isis Innovation Limited
- Inventors: Osnat Hakimi; Pierre-Alexis Mouthuy; Nasim Zargar Baboldashti; Andrew Carr
- Web page: https://patentgrep.com/patent/US10500310B2

## CPC

- A61L 27/38: {containing added animal cells (organs or tissue containing native cells A61L27/36)}
- A61F 13/02: Adhesive bandages or dressings
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 2300/64: Animal cells
- A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

## Claims

### Claim 1

A scaffold for tissue repair or wound dressing comprising:
i. a material layer;
ii. two or more polymer fibre layers; and
iii. an adhesive component between each of the layers, wherein the adhesive component comprises a polymer having a lower melting temperature (Tm) than the material layer and the polymer fibre layers,
wherein the adhesive component between the polymer fibre layers is porous and comprises electrospun fibres that are substantially arranged in a grid pattern, and wherein the adhesive component between the material layer and the polymer fibre layer is non-porous.

### Claim 2 (depends on 1)

The scaffold of claim 1, wherein the scaffold is biodegradable.

### Claim 3 (depends on 1)

The scaffold of claim 1, wherein the polymer fibre layers, material layer and/or the adhesive component comprises or consists of electrospun polymer.

### Claim 4 (depends on 1)

The scaffold of claim 1, wherein the polymer fiber layers, material layer and/or the adhesive component comprises a thermoplastic electrospun polymer.

### Claim 5 (depends on 3)

The scaffold of claim 3, wherein the polymer comprises polydioxanone (PDO).

### Claim 6 (depends on 1)

The scaffold of claim 1, wherein, the material layer and/or polymer fibre layers have a melting temperature (Tm) of at least about 70° C.

### Claim 7 (depends on 1)

The scaffold of claim 1, wherein the material layer comprises or consists of a woven component.

### Claim 8 (depends on 1)

The scaffold of claim 1, wherein the polymer fibre layers and/or adhesive component are formed from fibres.

### Claim 9 (depends on 1)

The scaffold of claim 1, wherein the material layer and the polymer layers comprise substantially the same polymer.

### Claim 10 (depends on 1)

The scaffold of claim 1, wherein the adhesive component has a melting temperature (Tm) of less than about 70° C.

### Claim 11 (depends on 1)

The scaffold of claim 1, wherein the adhesive component comprises polycaprolactone (PCL).

### Claim 12 (depends on 1)

The scaffold of claim 1, wherein the scaffold comprises two or more layers of the material layer and/or polymer fibre layers.

### Claim 13 (depends on 1)

The scaffold of claim 1, wherein the scaffold comprises one or more agents dispersed or impregnated therein; or coated or seeded thereon.

### Claim 14 (depends on 1)

The scaffold of claim 1, wherein the scaffold has a tensile strength of at least 30 Mpa and/or a breaking strain of at least 25%.

### Claim 15 (depends on 1)

The scaffold of claim 1, wherein the scaffold comprises cells.

### Claim 16 (depends on 1)

The scaffold of claim 1, wherein the adhesive component comprises polymer fibres electrospun into a grid.

### Claim 17 (depends on 1)

A method of treatment for a condition requiring the repair or replacement of damaged or degenerated tendon, ligament, bone and/or cartilage, comprising the use of the scaffold of claim 1 to repair, supplement or replace tissue.

### Claim 18 (depends on 1)

A method of treatment for a wound, comprising the application of the scaffold of claim 1 to the wound.