# US 10,500,302 B2 · Medical articles and methods of making using miscible composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,302 B2 - Document ID: US10500302B2 - Status: Granted - Kind: B2 - Application number: 12/942,434 - Filed: 2010-11-09 - Published: 2011-05-12 - Granted: 2019-12-10 - Earliest claimed: 2009-11-09 - Assignees: 3M Innovative Properties Company - Applicants: David R. Holm; Dong-Wei Zhu - Inventors: David R. Holm; Dong-Wei Zhu - Web page: https://patentgrep.com/patent/US10500302B2 ## CPC - A61L 15/58: Adhesives - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract Methods of improving the moisture vapor transmission rate of a pressure sensitive adhesive layer in a medical article with a miscible composition, as well as medical articles including the improved pressure sensitive adhesive layer. ## Claims ### Claim 1 A method of increasing moisture vapor transmission of an adhesive layer in a medical article, the method comprising: providing a PSA composition comprising a combination of hydrophilic polymer components and acid functional groups, the combination being greater than 15 wt %; wherein the hydrophilic polymer components are greater than 3 wt % and less than 30 wt %; wherein the acid functional groups are greater than 6 wt %, wherein all weight percentages are based on total weight of the PSA composition; forming a PSA layer from the PSA composition; providing an MVTR-modifying composition comprising an organic base, wherein the MVTR-modifying composition is not mixed within the PSA composition, but is miscible with the PSA composition; forming an MVTR-modifying layer from the MVTR-modifying composition; and placing the MVTR-modifying layer proximate the PSA layer under conditions effective for at least a portion of the MVTR-modifying composition to penetrate into the PSA composition to form a non-uniform dispersion throughout the PSA layer; wherein contact between the MVTR-modifying composition and the PSA composition causes an acid-base reaction to form a poly-salt and increase moisture permeability of at least a portion of the PSA layer. ### Claim 2 (depends on 1) The method of claim 1 wherein the MVTR-modifying composition further comprises a plasticizer. ### Claim 3 (depends on 2) The method of claim 2 wherein the plasticizer comprises glycerine, propylene glycol, sorbitol, xylitol, maltitol, polydextrose, glyceryl triacetate, lactic acid, urea, hydroxyethylurea, glucose, poly(vinyl alcohol), polyethylene glycols, liquid amines such as triethanolamine, diethanolamine, monoethanolamine, methyldiethanolamine, block copolymers of polyethylene glycol or propylene glycol, and combinations thereof. ### Claim 4 (depends on 1) The method of claim 1 wherein the PSA composition includes at least 0.84 mmoles acidic-functional groups per gram PSA composition. ### Claim 5 (depends on 1) The method of claim 1 wherein the PSA composition comprises a (meth)acrylate polymer, and wherein said polymer is prepared from at least 6 wt-% acidic- or basic-functional monomers, based on total weight of the PSA composition. ### Claim 6 (depends on 1) The method of claim 1 further comprising providing a backing, and forming a PSA layer on the backing before or after placing the MVTR-modifying layer proximate the PSA layer. ### Claim 7 (depends on 1) The method of claim 1 further comprising providing a pH-altering layer, and applying the pH-altering layer on the PSA layer after placing the MVTR-modifying layer proximate the PSA layer, wherein the pH-altering layer comprises a pH-altering material selected from a group consisting of citric acid, polyacrylic acid, and combinations thereof. ### Claim 8 (depends on 1) The method of claim 1 further comprising providing a filtration layer, and applying the filtration layer on the PSA layer after placing the MVTR-modifying layer proximate the PSA layer. ### Claim 9 (depends on 1) The method of claim 1 wherein the MVTR-modifying layer comprises an organic base selected from a group consisting of triethanolamine, methyldiethanolamine, pyridine, benzimidizole, histidine, triethylamine, monoethanolamine, diethanolamine, hydrates thereof, and combinations thereof. ### Claim 10 (depends on 1) The method of claim 1 wherein the medical article has a wet MVTR of at least 1200 g/m2/24 hours. ### Claim 11 (depends on 1) The method of claim 1 wherein the medical article is a wound dressing. ### Claim 12 A method of increasing moisture vapor transmission of an adhesive layer in a medical article, the method comprising: providing a PSA composition comprising a combination of hydrophilic polymer components and acid functional groups, the combination being greater than 15 wt %; wherein the hydrophilic polymer components are greater than 3 wt % and less than 30 wt %; wherein the acid functional groups are greater than 6 wt %, wherein all weight percentages are based on total weight of the PSA composition; forming a PSA layer from the PSA composition; providing an MVTR-modifying composition comprising an organic base, wherein the MVTR-modifying composition is not mixed within the PSA composition, but is miscible with the PSA composition; forming an MVTR-modifying layer from the MVTR-modifying composition; wherein forming an MVTR-modifying layer comprises: providing a scaffold; and coating the scaffold with the MVTR-modifying composition to form the MVTR-modifying layer; and placing the MVTR-modifying layer proximate the PSA layer. ### Claim 13 (depends on 1) A wound dressing prepared by the method of claim 1.