# US 10,500,301 B2 · Agent for salting out active principles in dressings containing at least one of fatty substance

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- Number: US 10,500,301 B2
- Document ID: US10500301B2
- Status: Granted
- Kind: B2
- Application number: 12/601,718
- Filed: 2008-05-23
- Published: 2010-11-11
- Granted: 2019-12-10
- Earliest claimed: 2007-05-25
- Assignees: Urgo Recherche Innovation Et Developpement
- Applicants: Christelle Laurensou
- Inventors: Christelle Laurensou
- Web page: https://patentgrep.com/patent/US10500301B2

## CPC

- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61K 31/505: Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K 31/7016: Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032)
- A61K 31/785: Polymers containing nitrogen
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61L 15/225: {Mixtures of macromolecular compounds}
- A61L 15/44: Medicaments
- A61L 26/0052: {Mixtures of macromolecular compounds}
- A61L 26/0066: {Medicaments; Biocides}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 23/02: Local anaesthetics
- A61P 29/02: without antiinflammatory effect
- A61P 31/04: Antibacterial agents
- A61L 2300/602: Type of release, e.g. controlled, sustained, slow
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to the use, as an agent for salting out an active substance in a composition for a dressing, of a copolymer of a salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid and the 2-hydroxyethyl ester of propenoic acid. It also relates to dressings of the type comprising at least one fatty substance and/or an elastomeric matrix and at least one active substance, which incorporate the aforementioned copolymer.

## Claims

### Claim 1

A dressing comprising a mass, wherein the mass comprises a hydrocolloid in an amount of between 2 and 20% by weight of the mass, at least one selected from the group consisting of a fatty substance and an elastomeric matrix, at least one active substance, and a copolymer of a salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid and of 2-hydroxyethylpropenoate ester,
wherein the copolymer is included in an amount sufficient for increasing an amount of the active substance that is released from the dressing as compared to that of a corresponding dressing that does not comprise the copolymer,
wherein the amount of the copolymer included in the dressing is between 1% to 20% by weight, and
wherein the amount of the active substance included in the dressing is between 0.01% and 15% by weight.

### Claim 2 (depends on 1)

The dressing as claimed in claim 1, wherein the salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid is a sodium salt.

### Claim 3 (depends on 1)

The dressing as claimed in claim 1, wherein said active substance is selected from the group consisting of bactericidal agents, bacteriostatic agents, agents for promoting healing, enzymes for promoting wound cleaning, protease inhibitors, metalloprotease inhibitors, painkillers, local anesthetics and nonsteroidal anti-inflammatory drugs.

### Claim 4 (depends on 1)

The dressing as claimed in claim 1, which comprises between 1% and 10% by weight of said copolymer.

### Claim 5 (depends on 1)

The dressing as claimed in claim 1, which comprises between 3% and 8% by weight of said active substance.

### Claim 6

A method for releasing an active substance from a dressing composition that comprises a mass, wherein the mass comprises a hydrocolloid in an amount of between 2 and 20% by weight of the mass and, at least one selected from the group consisting of a fatty substance and an elastomeric matrix and at least one active substance, the method comprising incorporating a copolymer of a salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid and of 2-hydroxyethylpropenoate ester in said dressing composition in an amount sufficient for increasing an amount of the active substance that is released from the dressing as compared to that of a corresponding dressing that does not comprise the copolymer,
wherein the amount of the copolymer incorporated in the dressing is between 1% to 20% by weight, and
wherein the amount of the active substance included in the dressing is between 0.01% and 15% by weight.

### Claim 7 (depends on 6)

The method as claimed in claim 6, wherein said salt of 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid is a sodium salt.

### Claim 8 (depends on 6)

The method as claimed in claim 6, wherein said active substance is selected from the group consisting of bactericidal agents, bacteriostatic agents, agents for promoting healing, enzymes for promoting wound cleaning, protease inhibitors, metalloprotease inhibitors, painkillers, local anesthetics and nonsteroidal anti-inflammatory drugs.

### Claim 9 (depends on 6)

The method as claimed in claim 6, wherein the composition comprises an elastomeric matrix.

### Claim 10 (depends on 3)

The dressing as claimed in claim 3, wherein said active substance is a bactericidal or bacteriostatic agent.

### Claim 11 (depends on 10)

The dressing as claimed in claim 10, wherein said active substance is selected from the group consisting of: chloramine, chlorhexidine, silver salts, zinc salts, metronidazole and penicillin.

### Claim 12 (depends on 11)

The dressing as claimed in claim 11, wherein said active substance is silver salts or zinc salts.

### Claim 13 (depends on 12)

The dressing as claimed in claim 12, wherein said active substance is silver salts.

### Claim 14 (depends on 3)

The dressing as claimed in claim 3, wherein said active substance is an agent for promoting healing.

### Claim 15 (depends on 14)

The dressing as claimed in claim 14, wherein said active substance is potassium sucrose octasulfate.

### Claim 16 (depends on 3)

The dressing as claimed in claim 3, wherein said active substance is a painkiller or local anesthetic.

### Claim 17 (depends on 16)

The dressing as claimed in claim 16, wherein said active substance is lidocaine or cinchocaine.

### Claim 18 (depends on 3)

The dressing as claimed in claim 3, wherein said active substance is a nonsteroidal anti-inflammatory drug.

### Claim 19 (depends on 18)

The dressing as claimed in claim 18, wherein said active substance is selected from the group consisting of: ibuprofen, ketoprofen, fenoprofen, and diclofenac.

### Claim 20 (depends on 1)

The dressing as claimed in claim 1, wherein the hydrocolloid is at least one selected from the group consisting of pectin, alginate, a natural plant gum, a cellulose derivative or an alkali metal salt thereof, and a superabsorbent.

### Claim 21 (depends on 1)

The dressing as claimed in claim 1, wherein the hydrocolloid is a carboxymethylcellulose or a sodium or calcium salt thereof.

### Claim 22 (depends on 21)

The dressing as claimed in claim 21, wherein the fatty substance is a paraffin oil, petroleum jelly, or a mineral oil formed from compounds of paraffinic, naphthenic or aromatic nature.

### Claim 23 (depends on 22)

The dressing as claimed in claim 22, wherein the active agent is a bacteriostatic silver salt, potassium sucrose octasulfate, lidocaine, cinchocaine, or a non-steroidal antiinflammatory drug.