# US 10,500,247 B2 · Method of treating low blood pressure

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- Number: US 10,500,247 B2
- Document ID: US10500247B2
- Status: Granted
- Kind: B2
- Application number: 15/870,139
- Filed: 2018-01-12
- Published: 2018-05-17
- Granted: 2019-12-10
- Earliest claimed: 2009-12-16
- Assignees: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
- Applicants: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
- Inventors: Lakhmir Chawla
- Web page: https://patentgrep.com/patent/US10500247B2

## CPC

- A61K 38/085: {Angiotensins}
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of Angiotensin II, or Ang II, to the patient.

## Claims

### Claim 1

A method of treating low blood pressure in a human patient suffering from acute kidney injury, refractory hypotension or severe hypotension, comprising administering angiotensin II to the patient at an initial rate from about 5 ng/kg/min to about 20 ng/kg/min.

### Claim 2 (depends on 1)

The method of claim 1, wherein the initial rate is about 5 ng/kg/min.

### Claim 3 (depends on 1)

The method of claim 1, wherein the initial rate is about 10 ng/kg/min.

### Claim 4 (depends on 1)

The method of claim 1, wherein the initial rate is about 20 ng/kg/min.

### Claim 5 (depends on 1)

The method of claim 1, wherein the initial rate is from about 10 ng/kg/min to about 20 ng/kg/min.

### Claim 6 (depends on 1)

The method of claim 1, wherein the method further comprises titrating the rate up.

### Claim 7 (depends on 6)

The method of claim 6, wherein the dose is titrated up to about 30 ng/kg/min.

### Claim 8 (depends on 6)

The method of claim 6, wherein the dose is titrated up to about 40 ng/kg/min.

### Claim 9 (depends on 1)

The method of claim 1, wherein the angiotensin II is administered to the patient over a period of about 0.25 hours to about 120 hours.

### Claim 10

A method of treating low blood pressure in a human patient suffering from acute kidney injury, refractory hypotension or severe hypotension, comprising administering angiotensin II to the patient at an initial rate from about 5 ng/kg/min to about 20 ng/kg/min; wherein the method further comprises titrating the rate up, and wherein the angiotensin II is administered to the patient over a period of about 0.25 hours to about 120 hours.

### Claim 11 (depends on 10)

The method of claim 10, wherein the initial rate is about 5 ng/kg/min.

### Claim 12 (depends on 10)

The method of claim 10, wherein the initial rate is about 10 ng/kg/min.

### Claim 13 (depends on 10)

The method of claim 10, wherein the initial rate is about 20 ng/kg/min.

### Claim 14 (depends on 10)

The method of claim 10, wherein the initial rate is from about 10 ng/kg/min to about 20 ng/kg/min.

### Claim 15 (depends on 10)

The method of claim 10, wherein the dose is titrated up to about 30 ng/kg/min.

### Claim 16 (depends on 10)

The method of claim 10, wherein the dose is titrated up to about 40 ng/kg/min.

### Claim 17 (depends on 1)

The method of claim 1, wherein the angiotensin II is human angiotensin II.

### Claim 18 (depends on 10)

The method of claim 10, wherein the angiotensin II is human angiotensin II.

### Claim 19 (depends on 5)

The method of claim 5, wherein the method further comprises titrating the rate up.

### Claim 20 (depends on 19)

The method of claim 19, wherein the dose is titrated up to about 30 ng/kg/min.

### Claim 21 (depends on 19)

The method of claim 19, wherein the dose is titrated up to about 40 ng/kg/min.

### Claim 22 (depends on 5)

The method of claim 5, wherein the angiotensin II is administered to the patient over a period of about 0.25 hours to about 120 hours.