# US 10,500,245 B2 · Compositions for preventing and/or treating pathological conditions associated with alpha-glucosidase

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- Number: US 10,500,245 B2
- Document ID: US10500245B2
- Status: Granted
- Kind: B2
- Application number: 15/119,032
- Filed: 2015-02-18
- Published: 2018-04-19
- Granted: 2019-12-10
- Earliest claimed: 2014-02-18
- Assignees: Universite De La Rochelle; Universite Clermont Auvergne
- Applicants: Universite De La Rochelle; Universite Blaise Pascal-Clermont II
- Inventors: Thierry Maugard; Stephanie Bordenave-Juchereau; Jean-Marie Piot; Yesmine Ben-Henda; Pascal Sirvent; Sebastien Peltier
- Web page: https://patentgrep.com/patent/US10500245B2

## CPC

- A61K 38/06: Tripeptides
- A23L 33/18: Peptides; Protein hydrolysates
- A23L 33/30: {Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence)}
- A61K 38/005: {Enzyme inhibitors (protease inhibitors A61K38/55)}
- A61K 38/01: Hydrolysed proteins; Derivatives thereof
- A61K 38/05: Dipeptides
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A composition including at least one XAP peptide, in which X represents the empty set or a valine, for use in the prevention and/or treatment of pathologies associated with alpha-glucosidase. Also, the use of a hydrolysate of at least one protein, the protein including or constituted by at least 0.05% to <5% or of at least 5% of XAP units, in which X represents the empty set or a valine, for use in the prevention and/or treatment of pathologies associated with alpha-glucosidase.

## Claims

### Claim 1

A method for reducing glycemia by inhibiting alpha-glucosidase, said method comprising administering to a subject in need thereof a composition comprising at least one XAP peptide, in which X represents the empty set or a valine, wherein the XAP peptide is administered before or during a meal.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said composition comprises at least one VAP peptide and/or at least one AP peptide in combination with a peptide APX′;
wherein A is alanine, P is proline, and X′ is an amino acid or a group of amino acids selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said composition is in unit form and comprises a quantity of XAP peptide from 5 mg to 3000 mg.

### Claim 4 (depends on 1)

The method according to claim 1, wherein said composition comprises a quantity of VAP peptide from 5 mg to 3000 mg, or a quantity of AP peptide from 5 mg to 3000 mg, or a quantity of VAP and AP peptides from 5 mg to 3000 mg.

### Claim 5 (depends on 4)

The method according to claim 4,
wherein said composition comprises:
a quantity of VAP peptide that is in a range selected from the group consisting of: from 5 mg to 7.4 mg, and from 7.5 mg to 3000 mg; or
a quantity of AP peptide that is in a range selected from the group consisting of: from 5 mg to 7.4 mg, and from 7.5 mg to 3000 mg; or
a quantity of VAP and AP peptides that is in a range selected from the group consisting of: from 5 mg to 7.4 mg, and from 7.5 mg to 3000 mg.