# US 10,500,244 B1 · Synthesis of black eggplant (Solanum melongena) skin antioxidant nanoparticles

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- Number: US 10,500,244 B1
- Document ID: US10500244B1
- Status: Granted
- Kind: B1
- Application number: 16/408,992
- Filed: 2019-05-10
- Granted: 2019-12-10
- Earliest claimed: 2019-05-10
- Assignees: King Saud University
- Applicants: King Saud University
- Inventors: Hany Mohamed Yehia; Mohamed Fekry Serag El-Din; Hatem Salama Mohamed Ali; Mohamed Saleh Alamri; Wafa Abdullah Al-Megrin; Manal Fawzy Elkhadragy; Manal Ahmed Gasmelseed Awad
- Web page: https://patentgrep.com/patent/US10500244B1

## CPC

- A61K 9/14: Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)}
- A61K 36/81: Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K 9/16: Agglomerates; Granulates; Microbeadlets {; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction (A61K9/20 takes precedence if the final form is a tablet; microspheres with drug-free outer coating, microcapsules A61K9/50; mixture of different granules, microcapsules, (coated) microparticles A61K9/5084; nanoparticles A61K9/51)}
- A61K 9/1682: {Processes}
- A61K 2236/00: Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K 2236/33: involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K 2236/39: Complex extraction schemes, e.g. fractionation or repeated extraction steps
- A61K 2236/51: Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The black eggplant skin antioxidant nanoparticles may be manufactured by extracting black eggplant skins in a solvent, spraying the black eggplant skin extracts into boiling water under ultrasonic conditions to produce a first mixture, sonicating the mixture, stirring the mixture, and drying the mixture to obtain black eggplant skin antioxidant nanoparticles. In an embodiment, the black eggplant skin may be skin of Solanum melongena. In an embodiment, the black eggplant skin nanoparticles may have improved antibacterial or antioxidant properties.

## Claims

### Claim 1

A method of synthesizing black eggplant skin nanoparticles, comprising:
(a) extracting black eggplant skins in a solvent to produce a black eggplant skin extract;
(b) spraying the black eggplant skin extract into boiling water under ultrasonic conditions to form a sonicated mixture;
(c) stirring the sonicated mixture to provide a stirred mixture; and
(d) drying the stirred mixture to obtain black eggplant skin nanoparticles.

### Claim 2 (depends on 1)

The method of synthesizing black eggplant skin nanoparticles according to claim 1, wherein the black eggplant skins are Solanum melongena skins.

### Claim 3 (depends on 2)

The method of synthesizing black eggplant skin nanoparticles according to claim 2, wherein the Solanum melongena skins are skins of Solanum melongena collected in Riyadh, Saudi Arabia.

### Claim 4 (depends on 1)

The method of synthesizing black eggplant skin nanoparticles according to claim 1, wherein the solvent is methanol.

### Claim 5 (depends on 1)

The method of synthesizing black eggplant skin nanoparticles according to claim 1, wherein about 500 mg of black eggplant skins are extracted in about 20 ml of solvent.

### Claim 6 (depends on 1)

The method of synthesizing black eggplant skin nanoparticles according to claim 1, wherein the black eggplant skin extract is sprayed into about 40 ml of the boiling water.

### Claim 7 (depends on 1)

The method of synthesizing black eggplant skin nanoparticles according to claim 1, wherein the black eggplant skin extract is sprayed into the boiling water dropwise, at a flow rate of about 0.2 ml per minute, for about 5 minutes.

### Claim 8 (depends on 1)

The method of synthesizing black eggplant skin nanoparticles according to claim 1, wherein the ultrasonic conditions include an ultrasonic power of 750 W and a frequency of 20 kHz.

### Claim 9 (depends on 8)

The method of synthesizing black eggplant skin nanoparticles according to claim 8, wherein the mixture is sonicated for about 10 minutes.

### Claim 10 (depends on 9)

The method of synthesizing black eggplant skin nanoparticles according to claim 9, wherein the sonicated mixture is stirred at 200-800 rpm at room temperature for about 20 minutes.