# US 10,500,243 B2 · Composition for cooling skin comprising phellodendron bark extract, method of preparing the same, topical composition comprising the same and dermatologically acceptable carrier, and method of cooling skin by applying the same

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- Number: US 10,500,243 B2
- Document ID: US10500243B2
- Status: Granted
- Kind: B2
- Application number: 16/237,456
- Filed: 2018-12-31
- Published: 2019-05-09
- Granted: 2019-12-10
- Earliest claimed: 2014-08-27
- Assignees: Yong Kyu Woo; Nature Four Co., Ltd
- Applicants: Yong Kyu Woo; Nature4 Co., Ltd
- Inventors: Yong Kyu Woo
- Web page: https://patentgrep.com/patent/US10500243B2

## CPC

- A61K 36/756: Phellodendron, e.g. corktree
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 36/534: Mentha (mint)
- A61K 36/539: Scutellaria (skullcap)
- A61K 36/65: Paeoniaceae (Peony family), e.g. Chinese peony
- A61K 36/75: Rutaceae (Rue family)
- A61K 36/8964: Anemarrhena
- A61P 17/00: Drugs for dermatological disorders
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61K 2236/13: involving cleaning, e.g. washing or peeling
- A61K 2236/331: using water, e.g. cold water, infusion, tea, steam distillation or decoction
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are a composition for cooling skin comprising a Phellodendron bark extract, a method of preparing the composition, a skin-improving product comprising the composition and a method of cooling skin by applying the composition to a skin of a subject, wherein the skin needs cooling. The composition prevents a burning sensation in the skin and under the skin and reduces heat generated under the skin and on the skin. The composition includes a Phellodendron bark extract as a main ingredient and further includes an extract of one or more selected from the group consisting of Anemarrhena asphodeloides, Scutellaria baicalensis, Paeonia lactiflora, Dictamnus dasycarpus, Alumen, Dryobalanops aromatic and Mentha arvensis.

## Claims

### Claim 1

A method of preparing a plant extract comprising:
(a) washing a plant with water, wherein the plant is Phellodendron bark; and
(b) putting the washed plant and a first solvent at a volume ratio of 1:12 to 1:42 in a vacuum extractor which contains a liquid phase extractor and a gas phase distillation part, and performing a vacuum extraction for 50-80 minutes at 60-80° C. to obtain a distillation solution in the gas phase distillation part and a liquid extract in the liquid phase extractor; and
(c) optionally, removing the first solvent from the liquid extract to obtain a concentrated extract,
wherein the distillation solution in (b) or the concentrated extract in (c) is the plant extract.

### Claim 2 (depends on 1)

The method according to claim 1 further comprising:
(d) adding Alumen to a second solvent in a volume ratio of 1:23 to 1:334 and performing a warm impregnation at 65-80° C. for 50-80 minutes and filtering to obtain a filtrate; and
(e) mixing the filtrate of (c) with the distillation solution of (b) in a volume ratio of 5:1 to 1:1 (the distillation solution of (b): the filtrate of (d)) to prepare a stock solution,
wherein the stock solution is the plant extract.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the first solvent is one or more selected from the group consisting of alcohol, glycols, oils and water.

### Claim 4 (depends on 2)

The method according to claim 2, wherein the second solvent is one or more selected from the group consisting of alcohol, glycols, oils and water.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the plant of (a) further comprises one or more selected from the group consisting of Anemarrhena asphodeloides, Scutellaria baicalensis, Paeonia lactiflora, Dictamnus dasycarpus, Alumen, Dryobalanops aromatic and Mentha arvensis.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the plant of (a) further comprises Anemarrhena asphodeloides, Scutellaria baicalensis, Paeonia lactiflora, Dictamnus dasycarpus, Alumen, Dryobalanops aromatic and Mentha arvensis.