# US 10,500,235 B2 · Wound healing compositions comprising buckwheat honey and methylglyoxal and methods of use

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- Number: US 10,500,235 B2
- Document ID: US10500235B2
- Status: Granted
- Kind: B2
- Application number: 15/010,896
- Filed: 2016-01-29
- Published: 2016-08-04
- Granted: 2019-12-10
- Earliest claimed: 2015-01-29
- Assignees: San Melix Laboratories, Inc.
- Applicants: SanMelix Laboratories, Inc.
- Inventors: Mark R. Wardell
- Web page: https://patentgrep.com/patent/US10500235B2

## CPC

- A61K 35/644: Beeswax; Propolis; Royal jelly; Honey
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/11: Aldehydes
- A61K 31/121: acyclic
- A61K 33/00: Medicinal preparations containing inorganic active ingredients
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 33/30: Zinc; Compounds thereof
- A61L 15/20: containing organic materials
- A61L 15/40: containing ingredients of undetermined constitution or reaction products thereof {, e.g. plant or animal extracts}
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61L 26/0057: {Ingredients of undetermined constitution or reaction products thereof}
- A61L 26/0066: {Medicaments; Biocides}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L 2300/216: with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
- A61L 2300/30: Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides compositions based on medicinal honey containing broad-spectrum antibacterial activities of peroxide, polyphenols and methylglyoxal, for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with the above composition or a wound dressing containing the above composition.

## Claims

### Claim 1

A wound healing composition consisting essentially of:
buckwheat honey; and
methylglyoxal in an amount of from about 500 to about 2000 mg per kg of the total composition.

### Claim 2 (depends on 1)

A wound healing dressing comprising:
the wound healing composition according to claim 1; and
a support.

### Claim 3 (depends on 2)

The wound healing dressing of claim 2, wherein the support is selected from the group consisting of a fibrous gauze material, a hydrogel, a foam, a film, a hydrocolloid, a collagen, an alginate, and a combination of two or more thereof.

### Claim 4 (depends on 2)

The wound healing dressing of claim 2, wherein the wound healing dressing is capable of being replaced on a wound at least once.