# US 10,500,219 B2 · Compositions and methods for tissue regeneration

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,500,219 B2
- Document ID: US10500219B2
- Status: Granted
- Kind: B2
- Application number: 14/693,239
- Filed: 2015-04-22
- Published: 2015-08-13
- Granted: 2019-12-10
- Earliest claimed: 2012-12-12
- Assignees: Orbis Health Solutions LLC
- Applicants: Orbis Health Solutions LLC
- Inventors: Thomas E. Wagner
- Web page: https://patentgrep.com/patent/US10500219B2

## CPC

- A61K 31/695: Silicon compounds
- A61K 8/585: {Organosilicon compounds}
- A61K 8/922: {of vegetable origin}
- A61K 9/0017: {Non-human animal skin, e.g. pour-on, spot-on}
- A61K 35/644: Beeswax; Propolis; Royal jelly; Honey
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/5777: {Theobroma, e.g. cocao or cocoa}
- A61K 36/63: Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K 36/736: Prunus, e.g. plum, cherry, peach, apricot or almond
- A61K 36/88: Liliopsida (monocotyledons)
- A61K 36/886: Aloeaceae (Aloe family), e.g. aloe vera
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/10: Anti-acne agents
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 19/00: Preparations for care of the skin
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Methods and compositions using an orthosilicate for tissue regeneration, such as to treat a disease or condition, are described, including on the skin. Also described are methods for making such compositions.

## Claims

### Claim 1

A method for treating acne, melanoma, or basal cell carcinoma in a human or animal in need thereof, comprising administering to the human or animal a cream or ointment comprising 10% to 40% (w/w) of tetraethylorthosilicate and an oil, wherein the acne, melanoma, or basal cell carcinoma in the human or animal is effectively treated.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the tetraethylorthosilicate is present in a concentration of 20% (w/w).

### Claim 3 (depends on 1)

The method according to claim 1, wherein the oil is selected from the group consisting of aloe vera oil, chamomile oil, geranium oil, jojoba oil, juniper oil, lavender oil, palm oil, sunflower oil, vanilla oil, almond oil, sweet almond oil, peanut oil, cashew oil, hazelnut oil, macadamia oil, mongongo nut oil, pecan oil, pine nut oil, pistachio oil, walnut oil, avocado oil, cocoa butter oil, coconut oil, corn oil, grapeseed oil, olive oil, sesame oil, rhea butter oil, and soybean oil.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the cream or ointment further comprises a component selected from the group consisting of an excipient, stabilizer, moisturizer, thickening agent, emulsifier, emollient, lubricant, surfactant, deodorizing agent, viscosity controlling agent, solvent, softening agent, alkalizing agent, vitamin, opacifying agent, solubilizer, plant extract, water, chelating agent, humectant, thickener, cryoprotectant, biocide, and nebulizer, anti-oxidant, lipid, peptide, protein, amino acid, anti-aging agent, anti-wrinkle agent, fragrance, essential oil, and preservative.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the oil is a combination of cocoa butter, bees wax and sweet almond oil.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the tetraethylorthosilicate is present in a concentration from 25% to 40% (w/w).

### Claim 7 (depends on 1)

The method according to claim 1, wherein total oil content is 10% to 90% by total weight of the cream or ointment.

### Claim 8 (depends on 1)

The method according to claim 1, wherein total oil content is 50% to 75% by total weight of the cream or ointment.

### Claim 9 (depends on 1)

The method according to claim 1, wherein the cream or ointment is administered 1, 2, 3, 4 or 5 times daily.

### Claim 10 (depends on 1)

The method according to claim 1, wherein the cream or ointment is administered for up to 1 month.

### Claim 11 (depends on 1)

The method according to claim 1, wherein the cream or ointment is administered for up to 2 months.

### Claim 12 (depends on 1)

The method according to claim 1, wherein the cream or ointment is not administered with another active agent.

### Claim 13 (depends on 1)

The method according to claim 1, wherein the cream or ointment further comprises one or more additional components selected from the group consisting of isopropyl palmitate, lecithin, cl2-15 alkyl benzoate, cetyl alcohol, cetearyl alcohol, ethylhexylglycerin, glycerin usp, glyceryl stearate, hydroxyethyl acrylate/sodium, acryloyldimethyl taurate copolymer, oleic acid, PEG 100 stearate, phenoxyethanol, polymethylsiloxane, purified water, stearic acid, trolamine NF, vitamin E, vitamin E acetate, ethylhexyl stearate, glycerol stearate, PEG 100 stearate, polysorbate-60, aloe, leaf juice, EDTA, sorbitol, cyclomethicone, isothiazolinone, propylene glycol, ceteareth 20, dimethicone, octyldodecanol, phenoxyethanol, and bees wax.

### Claim 14 (depends on 1)

The method according to claim 1, wherein when the acne, melanoma or basal cell carcinoma in the human or animal is treated tissue regeneration occurs.

### Claim 15 (depends on 1)

The method according to claim 1, wherein when the melanoma or basal cell carcinoma in the human or animal is treated a surface lesion resulting from the melanoma or basal cell carcinoma is also treated.