# US 10,500,212 B2 · Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof

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- Number: US 10,500,212 B2
- Document ID: US10500212B2
- Status: Granted
- Kind: B2
- Application number: 16/245,131
- Filed: 2019-01-10
- Published: 2019-05-23
- Granted: 2019-12-10
- Earliest claimed: 2012-04-03
- Assignees: Sanofi
- Applicants: Sanofi
- Inventors: Jean-Christophe Carry; Fabienne Chatreaux; Stephanie Deprets; Olivier Duclos; Vincent Leroy; Sergio Mallart; Dominique Melon-Manguer; Maria Mendez-Perez; Fabrice Vergne
- Web page: https://patentgrep.com/patent/US10500212B2

## CPC

- A61K 31/553: having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A61K 31/519: ortho- or peri-condensed with heterocyclic rings
- A61K 31/55: having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K 31/551: having two nitrogen atoms, e.g. dilazep
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 495/04: Ortho-condensed systems
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention relates to compounds of formula (I): wherein R6 is —CONH2 or a —C(Rα)(Rβ)(OH) group; R is a substituted phenyl or heteroaryl group; R7 is an optionally substituted aryl or heteroaryl group. Process for the preparation thereof and therapeutic use thereof.

## Claims

### Claim 1

A compound of formula (II):
wherein:
R7 is an aryl group or a heteroaryl group, wherein the aryl group or the heteroaryl group is optionally substituted with one or several substituents selected, independently in each instance, from the group consisting of cyano, halogen, (C1-C6)alkyl, OR′4, CH2OH, CH2NH2, S(O)nR′4, R8 and OR8;
wherein:
R′4 is a hydrogen atom, a (C1-C6)alkyl group or an aryl group, wherein the (C1-C6)alkyl group or the aryl group is optionally substituted with a halogen atom, an NH2 group or an OH group;
n is 1 or 2; and
R8 is a halo(C1-C6)alkyl group; and
R16 is a (C1-C6)alkoxy group;
or a pharmaceutically acceptable salt thereof.