# US 10,500,199 B2 · Nutritional supplement for increasing cognitive functions

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- Number: US 10,500,199 B2
- Document ID: US10500199B2
- Status: Granted
- Kind: B2
- Application number: 15/829,801
- Filed: 2017-12-01
- Published: 2019-06-06
- Granted: 2019-12-10
- Earliest claimed: 2017-12-01
- Assignees: Innovus Pharmaceuticals, Inc.
- Applicants: Innovus Pharmaceuticals, Inc.
- Inventors: Bassam Damaj
- Web page: https://patentgrep.com/patent/US10500199B2

## CPC

- A61K 31/4525: containing a five-membered ring with oxygen as a ring hetero atom
- A23L 33/175: Amino acids
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods are useful to increase oxygenation of the brain and to improve cognitive function.

## Claims

### Claim 1

A unit dosage form suitable for oral administration to a human comprising:
L-citrulline 500 mg±20 mg;
L-arginine 250 mg±20 mg; and
at least about 5 mg piperine.

### Claim 2 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 5.0 mg piperine.

### Claim 3 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 5.3 mg piperine.

### Claim 4 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 5.5 mg piperine.

### Claim 5 (depends on 1)

The unit dosage form of claim 1 that further comprises microcrystalline cellulose, silicon dioxide, and magnesium stearate.

### Claim 6 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 480 mg of L-citrulline.

### Claim 7 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 490 mg of L-citrulline.

### Claim 8 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 500 mg of L-citrulline.

### Claim 9 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 230 mg of L-arginine.

### Claim 10 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 240 mg of L-arginine.

### Claim 11 (depends on 1)

The unit dosage form of claim 1 that comprises at least about 250 mg of L-arginine.

### Claim 12 (depends on 1)

The unit dosage form of claim 1 that comprises:
about 500 mg of L-citrulline;
about 250 mg of L-arginine; and
about 5 mg of (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one.

### Claim 13 (depends on 1)

The unit dosage form of claim 1 wherein the piperine is synthetically produced piperine.

### Claim 14 (depends on 1)

The unit dosage form of claim 1 wherein the piperine is an extract from the fruit of Piper.

### Claim 15 (depends on 12)

The unit dosage form of claim 12 that further comprises microcrystalline cellulose, silicon dioxide, and magnesium sterate.

### Claim 16 (depends on 1)

The unit dosage form of claim 1 that is formulated as a capsule, powder, or liquid.

### Claim 17 (depends on 1)

A method to increase NO levels in the blood of a mammal comprising administering a unit dosage form of claim 1 to the mammal.

### Claim 18 (depends on 1)

A method to increase oxygenation of the brain in a mammal comprising administering a unit dosage form of claim 1 to the mammal.

### Claim 19 (depends on 1)

A method to improve cognitive function in a mammal comprising administering a unit dosage form of claim 1 to the mammal.