# US 10,500,187 B2 · Composition comprising plant phenols for preventing or reducing TEWL and associated disorders and diseases

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- Number: US 10,500,187 B2
- Document ID: US10500187B2
- Status: Granted
- Kind: B2
- Application number: 14/429,158
- Filed: 2013-09-12
- Published: 2015-08-27
- Granted: 2019-12-10
- Earliest claimed: 2012-09-21
- Assignees: Societe des Produits Nestle S.A.
- Applicants: Nestec S.A.
- Inventors: Carine Blanchard; Marjorie Guitard; Sebastien Holvoet
- Web page: https://patentgrep.com/patent/US10500187B2

## CPC

- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A23C 9/13: using additives
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula}
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A61K 36/185: Magnoliopsida (dicotyledons)
- A61K 36/53: Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K 36/742: {Coffea, e.g. coffee}
- A61P 17/00: Drugs for dermatological disorders
- A61P 37/00: Drugs for immunological or allergic disorders
- A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q 19/007: {Preparations for dry skin}
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61Q 19/08: Anti-ageing preparations
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Plant phenols, in particular, plant phenolic acids, like rosmarinic acid, ellagic acid, and chlorogenic acid, are used in preventing or reducing transepidermal water loss (TEWL) and associated disorders and diseases.

## Claims

### Claim 1

A method for treatment of a transepidermal water loss (TEWL) disorder and/or increasing skin hydration in an individual in need thereof, the method comprising orally administering to the individual a composition consisting of (i) plant phenols, (ii) an amino acid selected from the group consisting of hydroxylysine, hydroxyserine and combinations thereof, (iii) a source of lipids, (iv) a source of carbohydrates, (v) optionally a vitamin, (vi) optionally a mineral, (vii) optionally an anti-oxidant, and (viii) optionally a component selected from the group consisting of stabilizers and emulgators.

### Claim 2 (depends on 1)

The method according to claim 1 wherein the individual has atopic dermatitis, dry or reactive skin, eczema, or skin dehydration.

### Claim 3 (depends on 1)

The method of claim 1 wherein the plant phenols are selected from the group consisting of rosmarinic acid, ellagic acid, cholorgenic acid, and mixtures thereof.

### Claim 4 (depends on 1)

The method according to claim 1 wherein the individual has atopic dermatitis or eczema.

### Claim 5 (depends on 1)

The method of claim 1 wherein the individual is a human or a pet.

### Claim 6 (depends on 1)

The method of claim 1 wherein the individual is selected from the group consisting of a young child between the age of 1 month and six years, an older child between the age of 6 to 18 years, and an adult.

### Claim 7 (depends on 1)

The method of claim 1 wherein the composition is administered to the individual in a dose comprising 300 mg to 1 g of the plant phenols/kg of body weight per day.

### Claim 8 (depends on 1)

The method of claim 1, wherein the composition is administered to the individual in a dose ranging from 25 mg to 10 g of the plant phenols per day.

### Claim 9 (depends on 1)

The method of claim 1 wherein a vitamin is present and is selected from the group consisting of Vitamin A, Vitamin E, Vitamin C, Vitamin Bi, Vitamin B2, Pantothenic Acid, Vitamin B6, Vitamin B12, Niacin, Folic Acid, Biotin, Choline, and combinations thereof.

### Claim 10 (depends on 1)

The method of claim 1 wherein the composition is administered to the individual for at least 120 days.

### Claim 11 (depends on 1)

The method of claim 1 wherein the plant phenols are rosmarinic acid.

### Claim 12 (depends on 1)

The method of claim 1, wherein the composition is an oral nutritional supplement.

### Claim 13

A method for treatment of a transepidermal water loss (TEWL) disorder and/or increasing skin hydration, in an individual in need thereof, the method comprising orally administering to the individual a composition comprising plant phenols and an amino acid selected from the group consisting of hydroxylysine, hydroxyserine and combinations thereof.