Glycine for use in tolerance induction in allergic patients
AssigneeN. V. Nutricia
InventorAnita Hartog
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Abstract
The invention relates to a free glycine source for use in inducing tolerance against an allergen, or preventing the development of allergy in a human or other mammal. The invention further relates to a composition comprising protein, fat and carbohydrates with at least 7 en % protein and at least 60 mg free glycine source per gram protein, preferably at least 70 mg glycine per gram protein. The free glycine source is preferably the free amino acid glycine, a salt of the free amino acid glycine, or a combination thereof; the protein can be intact protein, hydrolysed protein, peptides, free amino acids, salts of amino acids, or combinations thereof.
Claims18
A method for inducing or improving tolerance against a food allergen in a human, comprising administering to the human a composition comprising at least one glycine source selected from the group consisting of an amino acid glycine, physiologically acceptable salts of the amino acid glycine, dipeptides having at least one glycine unit, tripeptides having at least one glycine unit and tetrapeptides having at least one glycine, the composition comprising at least 7 en % protein, wherein the protein is selected from the group consisting of hydrolysed protein, peptides, amino acids, salts of amino acids, and a combination thereof, and the total content of glycine provided by the glycine source is 60-350 mg/g total protein.
A composition comprising protein, fat and carbohydrate, having at least 7 en % protein, wherein the protein is selected from the group consisting of hydrolysed protein, peptides, amino acids, salts of amino acids, and a combination thereof and at least 60 mg of a glycine source selected from the group consisting of an amino acid glycine, physiologically acceptable salts of the amino acid glycine, dipeptides having at least one glycine unit, tripeptides having at least one glycine unit and tetrapeptides having at least one glycine per gram protein and the protein consists of at least 80 wt % hydrolysed protein based on total weight of the protein in the composition.
A method for inducing or improving tolerance against an allergen in a human, comprising administering to the human, a composition comprising at least one glycine source selected from the group consisting of an amino acid glycine, physiologically acceptable salts of the amino acid glycine, dipeptides having at least one glycine unit, tripeptides having at least one glycine unit and tetrapeptides having at least one glycine unit, the composition comprising at least 7 en % protein, wherein the protein is selected from the group consisting of hydrolysed protein, peptides, amino acids, salts of amino acids, or a combination thereof, and the total content of glycine provided by the glycine source is 60-350 mg/g total protein.
Dependencies are inferred from the claim text.