# US 10,500,173 B2 · Antimicrobial silicone-based wound dressings > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,173 B2 - Document ID: US10500173B2 - Status: Granted - Kind: B2 - Application number: 13/163,224 - Filed: 2011-06-17 - Published: 2011-12-22 - Granted: 2019-12-10 - Earliest claimed: 2010-06-17 - Assignees: Covalon Technologies Inc. - Applicants: Liu Yang; Valerio DiTizio - Inventors: Liu Yang; Valerio DiTizio - Web page: https://patentgrep.com/patent/US10500173B2 ## CPC - A61K 31/155: Amidines ([IMAGE cpc-sch-A61K-1029.gif]), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2) - A61K 33/38: Silver; Compounds thereof - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61L 2/232: layered or coated - A61L 15/44: Medicaments - A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria - A61L 15/60: Liquid-swellable gel-forming materials, e.g. super-absorbents - A61L 26/0066: {Medicaments; Biocides} - A61L 26/008: {Hydrogels or hydrocolloids} - A61P 31/02: Local antiseptics - A61L 2300/104: Silver, e.g. silver sulfadiazine - A61L 2300/206: Biguanides, e.g. chlorohexidine - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/442: Colorants, dyes - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract Antimicrobial silicone-based dressings, such as wound dressings, are disclosed. An example dressing comprises a transparent and self-adhesive gel sheet cured from a liquid containing silicone, the sheet having dispersed therein (i) particulates of a chlorhexidine compound that is not soluble in the liquid; and (ii) at least one other antimicrobial. Methods of making the silicone-based dressings and methods of use are also disclosed. ## Claims ### Claim 1 A dressing consisting of a transparent and self-adhesive gel sheet cured from a liquid containing silicone and formed for adhesion to a wound site or surgical site on a patient, the cured gel sheet formed of a crosslinked silicone elastomer having sufficient crosslinking between silicone polymer chains so that the gel sheet is cohesively strong thereby allowing for application and subsequent removal from the wound site or surgical site while leaving substantially no residue, the cured gel sheet having from 95 wt % to 98 wt % of the crosslinked silicone elastomer and having evenly dispersed throughout the crosslinked silicone elastomer (i) solid particulates of chlorhexidine diacetate that is not soluble in said liquid, at a concentration so as not to disrupt the crosslinking between silicone polymer chains and the self-adhesiveness and cohesive strength of the gel sheet; and (ii) chlorhexidine digluconate, and a silver agent, the silver agent photo-stabilized with a compound containing a basic nitrogen atom to complex with the silver and a dye; the total amount of chlorhexidine present in the cured gel sheet being from 2 wt % to 5 wt %, and the amount of the silver agent present in the cured gel sheet being from 0.025 wt % to 0.5 wt %. ### Claim 2 (depends on 1) The dressing of claim 1, wherein said photo-stabilized silver agent is silver nitrate, silver acetate or silver lactate, or any combination thereof. ### Claim 3 (depends on 1) The dressing of claim 1, wherein said compound containing a basic nitrogen atom is D,L-pyroglutamic acid. ### Claim 4 (depends on 3) The dressing of claim 3, wherein said dye is Brilliant Green, Malachite Green, Methylene Blue, Ethyl Violet, Crystal Violet, Victoria Blue R, Victoria Blue B or Victoria Pure Blue BO, or any combination thereof. ### Claim 5 (depends on 3) The dressing of claim 3, wherein said dye is Brilliant Green. ### Claim 6 (depends on 1) The dressing of claim 1, wherein said dressing is provided as an I.V. dressing, a wound dressing, a wound barrier, a strip, a first aid bandage or a surgical drape. ### Claim 7 (depends on 1) The dressing of claim 1, wherein said dressing has a thickness of up to about 5 mm. ### Claim 8 A dressing consisting of (a) a transparent and self-adhesive gel sheet cured from a liquid containing silicone and formed for adhesion to a wound site or surgical site on a patient, the cured gel sheet formed of a crosslinked silicone elastomer having sufficient crosslinking between silicone polymer chains so that the gel sheet is cohesively strong thereby allowing for application and subsequent removal from the wound site or surgical site while leaving substantially no residue, the cured gel sheet having from 95 wt % to 98 wt % of the crosslinked silicone elastomer and having evenly dispersed throughout the crosslinked silicone elastomer (i) solid particulates of chlorhexidine diacetate that is not soluble in said liquid, at a concentration so as not to disrupt the crosslinking between silicone polymer chains and the self-adhesiveness and cohesive strength of the gel sheet; and (ii) chlorhexidine digluconate, and a silver agent, the silver agent photo-stabilized with a compound containing a basic nitrogen atom to complex with the silver and a dye; the total amount of chlorhexidine present in the cured gel sheet being from 2 wt % to 5 wt %, and the amount of the silver agent present in the cured gel sheet being from 0.025 wt % to 0.5 wt %; and (b) a non-adhesive, moisture vapor permeable backing layer layered on a bottom surface of the cured gel sheet, the top surface of the cured gel sheet being able to adhere to the skin of a subject without any additional adhesive.