# US 10,500,169 B2 · Supression of IgE production by compounds derived from traditional chinese medicine

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- Number: US 10,500,169 B2
- Document ID: US10500169B2
- Status: Granted
- Kind: B2
- Application number: 14/857,772
- Filed: 2015-09-17
- Published: 2016-06-23
- Granted: 2019-12-10
- Earliest claimed: 2014-09-17
- Assignees: Xiu-Min Li; Sean N. Parker Foundation
- Applicants: Xiu-Min Li; Sean N. Parker Foundation
- Inventors: Xiu-Min Li; Nan Yang; Chaoyi Mao; Ying Song; Sean N. Parker
- Web page: https://patentgrep.com/patent/US10500169B2

## CPC

- A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K 31/12: Ketones
- A61K 31/35: having six-membered rings with one oxygen as the only ring hetero atom
- A61K 31/366: having six-membered rings, e.g. delta-lactones
- A61K 31/4745: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines (yohimbine derivatives, vinblastine A61K31/475; ergoline derivatives A61K31/48)
- A61K 31/475: having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine (vincamine A61K31/4375)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to compounds and formulations derived from traditional Chinese medicine for use for the treatment and/or mediation of food allergies, in particular peanut allergies in humans by altering the activity and/or production of IgE.

## Claims

### Claim 1

A method for treating and/or mitigating a food allergy in a subject in need thereof, which method comprises administering to the subject a therapeutically effective amount of an isolated and purified compound selected from the group consisting of berberine, limonin, and 1,3-Dihydroxyanthraquinone, or a combination of isolated and purified compounds selected from the group consisting of berberine, limonin, and 1,3-Dihydroxyanthraquinone.

### Claim 2 (depends on 1)

The method of claim 1 where the food allergy is peanut allergy.

### Claim 3 (depends on 1)

The method of claim 1 wherein the subject is human.