# US 10,500,168 B2 · Use of licochalcone a for treatment of rosacea > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,500,168 B2 - Document ID: US10500168B2 - Status: Granted - Kind: B2 - Application number: 10/985,733 - Filed: 2004-11-10 - Published: 2005-08-25 - Granted: 2019-12-10 - Earliest claimed: 2003-11-10 - Assignees: Beiersdorf AG - Applicants: Franz Stäb; Rainer Wolber; Christopher Mummert; Ludger Kolbe; Jan Batzer; Kerstin Eggers; Anette Bürger - Inventors: Franz Stäb; Rainer Wolber; Christopher Mummert; Ludger Kolbe; Jan Batzer; Kerstin Eggers; Anette Bürger - Web page: https://patentgrep.com/patent/US10500168B2 ## CPC - A61K 31/12: Ketones - A61K 36/484: Glycyrrhiza (licorice) - A61P 17/00: Drugs for dermatological disorders - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention relates to preparations, particularly cosmetic and dermatological preparations, comprising a Radix Glycyrrhizae inflatae extract. In one embodiment, the extract includes licochalcone A. The preparations are useful for the treatment or prevention of rosacea. The invention also relates to methods of treating or preventing rosacea comprising applying Radix Glycyrrhizae inflatae extract, particularly including licochalcone A. In one embodiment, the Radix Glycyrrhizae inflatae extract is part of a cosmetic or dermatological preparation. ## Claims ### Claim 1 A cosmetic or dermatological preparation suitable for the treatment of rosacea, wherein the preparation is at least one of an emulsion, a hydrodispersion or a lipodispersion and comprises water, an aqueous extract of Radix Glycyrrhiza inflata that comprises Licochalcone A, and one or more of a polyol, an antioxidant, and a UV filter substance, and wherein the preparation is formulated to be suitable for application to human skin and comprises at least 0.01 wt. % of Licochalcone A, based on a total weight of the preparation. ### Claim 2 (depends on 1) The preparation of claim 1, wherein the preparation is an emulsion. ### Claim 3 (depends on 2) The preparation of claim 2, wherein the preparation is an O/W emulsion. ### Claim 4 (depends on 2) The preparation of claim 2, wherein the preparation is a W/O emulsion. ### Claim 5 (depends on 1) The preparation of claim 1, wherein the preparation comprises at least one polyol and at least one antioxidant. ### Claim 6 (depends on 1) The preparation of claim 1, wherein the preparation comprises up to 1 wt. % of Licochalcone A. ### Claim 7 (depends on 1) The preparation of claim 1, wherein the aqueous extract is present in a concentration of up to 10 wt. %, based on a total weight of the preparation. ### Claim 8 (depends on 7) The preparation of claim 7, wherein the aqueous extract is present in a concentration of up to 2 wt. %. ### Claim 9 (depends on 1) The preparation of claim 1, wherein the preparation comprises one or more polyols which comprise at least one of butylene glycol and glycerol. ### Claim 10 (depends on 9) The preparation of claim 9, wherein the one or more polyols comprise glycerol. ### Claim 11 (depends on 9) The preparation of claim 9, wherein the one or more polyols are present in a concentration of from 0.01 wt. % to 10 wt. %, based on a total weight of the preparation. ### Claim 12 (depends on 9) The preparation of claim 9, wherein the one or more polyols are present in a concentration of at least 2.5 wt. %. ### Claim 13 (depends on 1) The preparation of claim 1, wherein the preparation has a pH of from 4.0 to 6.5. ### Claim 14 (depends on 1) The preparation of claim 1, wherein the preparation further comprises a thickener. ### Claim 15 (depends on 14) The preparation of claim 14, wherein the preparation comprises at least one of polyacrylic acid, xanthan gum, and a PVP hexadecene copolymer. ### Claim 16 (depends on 1) The preparation of claim 1, wherein the UV filter substance comprises at least one of titanium dioxide and zinc oxide. ### Claim 17 A cosmetic or dermatological preparation, wherein the preparation is an emulsion, has a pH of from 4.0 to 6.5, and comprises an aqueous extract of Radix Glycyrrhiza inflata that comprises Licochalcone A, water, glycerol, and at least one of an antioxidant and a UV filter substance, and wherein the preparation is formulated to be suitable for application to human skin and comprises Licochalcone A in a concentration which renders the preparation effective for treating rosacea. ### Claim 18 (depends on 17) The preparation of claim 17, wherein the preparation comprises at least 0.01 wt. % of Licochalcone A, based on a total weight of the preparation. ### Claim 19 (depends on 18) The preparation of claim 18, wherein the preparation comprises at least 2.5 wt.-% of glycerol, based on a total weight of the preparation. ### Claim 20 (depends on 19) The preparation of claim 19, wherein the preparation comprises one or more UV filter substances. ### Claim 21 (depends on 20) The preparation of claim 20, wherein the one or more UV filter substances comprise at least one of titanium dioxide and zinc oxide. ### Claim 22 (depends on 19) The preparation of claim 19, wherein the preparation further comprises a thickener. ### Claim 23 (depends on 22) The preparation of claim 22, wherein the preparation comprises at least one of polyacrylic acid, xanthan gum, and a PVP hexadecene copolymer. ### Claim 24 A cosmetic or dermatological preparation, wherein the preparation is an emulsion, comprises an aqueous extract of Radix Glycyrrhiza inflata that comprises Licochalcone A, water, glycerol, and at least one of a UV filter substance and a thickener, and wherein the preparation has a pH of from 4.0 to 6.5, comprises at least 0.01 wt. % of Licochalcone A, and is effective for treating rosacea. ### Claim 25 (depends on 24) The preparation of claim 24, wherein the preparation comprises at least 2.5 wt.-% of glycerol, based on a total weight of the preparation. ### Claim 26 (depends on 24) The preparation of claim 24, wherein the preparation is an O/W cream. ### Claim 27 (depends on 24) The preparation of claim 24, wherein the preparation comprises at least one of polyacrylic acid, xanthan gum, and a PVP hexadecene copolymer. ### Claim 28 (depends on 24) The preparation of claim 24, wherein the preparation comprises at least one of titanium dioxide and zinc oxide.