# US 10,500,164 B2 · Nanoparticle-based combinatorial therapy

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- Number: US 10,500,164 B2
- Document ID: US10500164B2
- Status: Granted
- Kind: B2
- Application number: 15/512,288
- Filed: 2015-09-18
- Published: 2017-09-14
- Granted: 2019-12-10
- Earliest claimed: 2014-09-19
- Assignees: The American University in Cairo
- Applicants: The American University in Cairo
- Inventors: Nancy Mohamed Elbaz; Wael Mamdouh Sayed Sayed Ahmed; Laila Ziko; Rania Siam
- Web page: https://patentgrep.com/patent/US10500164B2

## CPC

- A61K 9/5115: {Inorganic compounds}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/5138: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates}
- A61K 9/5146: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides}
- A61K 31/704: attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides a nano-particle based structure or composition for a combinational cancer therapy. The structure has a doxorubicin (DOX) physically loaded on core-shell silver polymeric nanoparticles (AgN-Ps) with a ratio of 3.3-5.5% doxorubicin to 1% silver to 2-10% polymer. This structure enhances the cellular uptake of DOX in comparison to the current conventional combination therapy. The DOX-loaded nano-particles result in an improved the therapeutic efficiency of DOX, and reduced its toxicity, which cannot occur in case of adding DOX and AgNPs.

## Claims

### Claim 1

A nano-particle based composition for a combinational therapy for treatment of breast cancer comprising: doxorubicin physically loaded on core-shell silver polymeric nanoparticles with a ratio of 3.3-5.5 parts doxorubicin to 1 part silver to 2-10 parts polymer,
wherein the core-shell silver polymeric nanoparticles comprises the silver in the core and the shell comprises the polymer,
wherein the polymer is poly-vinyl alcohol (PVA), poly-ethylene glycol (PEG), or poly-vinyl pyrrolidone (PVP),
wherein the doxorubicin is present in the silver core,
wherein the silver core is stabilized by sodium citrate,
wherein the concentration of the doxorubicin in the composition is less or equal to 0.2 μg/ml, and
wherein the core-shell silver polymeric nanoparticles act as nanocarriers and anti-cancer agents for the treatment of breast cancer.

### Claim 2 (depends on 1)

The composition as set forth in claim 1, wherein each core-shell silver polymeric nanoparticle has a width of 5 nm to 20 nm.

### Claim 3 (depends on 1)

The composition as set forth in claim 1, wherein each core-shell silver polymeric nanoparticle has a width of 20 nm to 40 nm.