# US 10,500,142 B2 · Oral care compositions

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- Number: US 10,500,142 B2
- Document ID: US10500142B2
- Status: Granted
- Kind: B2
- Application number: 15/393,807
- Filed: 2016-12-29
- Published: 2017-08-17
- Granted: 2019-12-10
- Earliest claimed: 2015-12-30
- Assignees: Colgate-Palmolive Company
- Applicants: Colgate-Palmolive Company
- Inventors: Daniel Schankel; Shiri Nawrocki; Viktor Dubovoy; Long Pan; Nihal Dogu
- Web page: https://patentgrep.com/patent/US10500142B2

## CPC

- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/19: containing inorganic ingredients
- A61K 8/21: Fluorides; Derivatives thereof
- A61K 8/55: Phosphorus compounds
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K 2800/58: Metal complex; Coordination compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride and a pyrophosphate salt and oral care compositions comprising the complexes and uses thereof.

## Claims

### Claim 1

An oral care composition comprising an aqueous soluble tin phosphate complex formed from a mixture comprising tin (II) fluoride, and a pyrophosphate salt; wherein the complex comprises tin, phosphate and fluoride; and wherein the complex is formed from a mixture comprising the tin (II) fluoride and pyrophosphate salt in a molar ratio of 1P:1Sn to 10P:1Sn, and wherein the complex is present in an amount of 2 to 30 weight % by weight of the composition, wherein the complex is formed in situ in an aqueous solution and combined with an oral care base, or wherein the complex is isolated from the aqueous solution in solid form and combined with the oral care base, or wherein the complex is lyophilized and combined with the oral care base, or wherein the complex is isolated with an anti-solvent and combined with the composition.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the oral care base is a mouthwash base, an oral gel or a dentifrice base.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride by weight of the mixture and 1 to 40 weight % pyrophosphate salt by weight of the mixture.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the pyrophosphate salt is tetrapotassium pyrophosphate (K4P2O7).

### Claim 5 (depends on 4)

The composition of claim 4, wherein the complex is formed from a mixture comprising the tin (II) fluoride and tetrapotassium pyrophosphate in a molar ratio of at least 1P:1Sn.

### Claim 6 (depends on 4)

The composition of claim 4, wherein the complex is formed from a mixture comprising the tin (II) fluoride and tetrapotassium pyrophosphate in a molar ratio of 1P:1Sn to 10P:1Sn.

### Claim 7 (depends on 4)

The composition of claim 4, wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride by weight of the mixture and 1 to 40 weight % tetrapotassium pyrophosphate by weight of the mixture.

### Claim 8 (depends on 1)

The composition of claim 1, wherein the pyrophosphate salt is tetrasodium pyrophosphate (Na4P2O7).

### Claim 9 (depends on 8)

The composition of claim 8, wherein the complex is formed from a mixture comprising the tin (II) fluoride and tetrasodium pyrophosphate in a molar ratio of 1P:1Sn to 5P:1Sn.

### Claim 10 (depends on 8)

The composition of claim 8, wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride by weight of the mixture and 1 to 30 weight % tetrasodium pyrophosphate by weight of the mixture.

### Claim 11 (depends on 8)

The composition of claim 8, wherein the tin (II) fluoride and tetrasodium pyrophosphate (Na4P2O7) form a complex having the formula [P2O7]4−Na2+Sn2+2F−.

### Claim 12 (depends on 1)

The composition of claim 1, wherein the composition comprises an aqueous solution.

### Claim 13 (depends on 1)

The composition of claim 1 further comprising more than 20 weight % water by weight of the composition.

### Claim 14 (depends on 1)

The composition of claim 1, wherein the composition is a mouthwash.

### Claim 15 (depends on 1)

The composition of claim 1 for use to reduce dentinal hypersensitivity.

### Claim 16 (depends on 1)

A method to reduce or inhibit dentinal hypersensitivity, dental caries, gingivitis, or plaque in a person in need thereof comprising applying an effective amount of an oral care composition as claimed in claim 1 to teeth of the person.