# US 10,500,140 B2 · Microparticle composition and use thereof

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- Number: US 10,500,140 B2
- Document ID: US10500140B2
- Status: Granted
- Kind: B2
- Application number: 16/330,171
- Filed: 2017-09-05
- Published: 2019-07-18
- Granted: 2019-12-10
- Earliest claimed: 2016-09-05
- Assignees: Spheritech Ltd
- Applicants: Spheritech Ltd.
- Inventors: Donald A. Wellings
- Web page: https://patentgrep.com/patent/US10500140B2

## CPC

- A61K 8/0245: {Specific shapes or structures not provided for by any of the groups of A61K8/0241}
- A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)}
- A61K 8/0275: {Containing agglomerated particulates}
- A61K 8/0279: {Porous; Hollow}
- A61K 8/362: Polycarboxylic acids
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/41: Amines
- A61K 8/49: containing heterocyclic compounds
- A61K 8/4926: {having six membered rings}
- A61K 8/4946: {Imidazoles or their condensed derivatives, e.g. benzimidazoles}
- A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof
- A61K 8/88: Polyamides
- A61Q 17/005: {Antimicrobial preparations}
- A61Q 19/00: Preparations for care of the skin
- C11D 3/2082: {Polycarboxylic acids-salts thereof}
- C11D 3/28: Heterocyclic compounds containing nitrogen in the ring
- C11D 3/30: Amines; Substituted amines {; Quaternized amines}
- C11D 17/06: Powder; Flakes; Free-flowing mixtures; Sheets
- C08G 69/10: Alpha-amino-carboxylic acids {(polysuccinimides C08G73/1092)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C11D: DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS

## Abstract

The invention provides a personal care product or a home care product having self-assembled microparticles having an acid having two or more acid groups and an organic base in a solvent. The microparticles may form into a macrostructure and provide a support for carrying components of a personal care or home care composition. The particle is of micron scale. The microparticle may be obtained by contacting a bis-acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.

## Claims

### Claim 1

A personal care product or a home care product comprising a base composition and a particulate component comprising a self-assembled microparticle having a particle size of 0.5 to 10 microns which comprises an acid having two or more acid groups comprising one or more of brassylic acid, sebacic acid and/or azelaic acid and an organic base comprising one or more of N-methylmorpholine,N,N-dimethylaminoethanol, 4-dimethylaminopyridine, imidazole, 1-methylamidazole poly(diallyldimethylammonium chloride) (PDAC), didecyldimethylammonium chloride (DDAC), dodecyldipropylenetriamine (DDPT) and poly epsilon lysine;
wherein the personal care product or home care product further comprises a base composition selected from a detergent composition, a fabric softener a fragrance and a dishwashing composition, if a home care product, and selected from a skin cream, cosmetic, fragrance, deodorant, hand or face wipe, hand wash, hand scrub, shampoo, conditioner, mouth wash and tooth paste, if a personal care product.

### Claim 2 (depends on 1)

A personal care product or a home care product according to claim 1 in which the microparticle has a particle size of 1 to 5 microns.

### Claim 3 (depends on 1)

A personal care product or a home care product according to claim 1 in which the molar ratio of acid groups to basic groups in the acid and base is from 0.6 to 1.4:1.

### Claim 4 (depends on 1)

A personal care product or a home care product according to claim 1 in which the microparticle comprises acid groups and basic groups in a molar ratio from 0.7 to 1.3:1.

### Claim 5 (depends on 1)

A personal care product or a home care product according to claim 1 in which the microparticle comprises a self-assembled microparticle obtainable by a process comprising contacting the acid and organic base in a hydrophilic solvent, wherein the acid is insoluble or sparingly soluble in the hydrophilic solvent and the organic base is soluble in a hydrophilic solvent.

### Claim 6 (depends on 5)

A personal care product or a home care product according to claim 5 in which the solvent comprises an aqueous solution.

### Claim 7 (depends on 1)

A personal care product or a home care product according to claim 1 in which the microparticle further comprises a bis acid of general formula HOOC—(CH2)n—COOH wherein n is sufficiently large that the bis acid is sparingly soluble or insoluble in water.