# US 10,499,923 B2 · Devices and methods for reshaping blood vessels

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- Number: US 10,499,923 B2
- Document ID: US10499923B2
- Status: Granted
- Kind: B2
- Application number: 15/905,415
- Filed: 2018-02-26
- Published: 2018-06-28
- Granted: 2019-12-10
- Earliest claimed: 2014-06-08
- Assignees: Sano V Pte Ltd
- Applicants: Sano V Pte Ltd
- Inventors: Eitan Konstantino; Gary Binyamin; Steven Wiesner; Li Min Koh
- Web page: https://patentgrep.com/patent/US10499923B2

## CPC

- A61B 17/12109: {in a blood vessel}
- A61B 17/0644: {penetrating the tissue, deformable to closed position}
- A61B 17/068: Surgical staplers {, e.g. containing multiple staples or clamps}({staplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105;} for performing anastomosis A61B17/115; {staplers in general B25C5/00})
- A61B 17/12: for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B 17/12036: {partial occlusion}
- A61B 17/12145: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)}
- A61F 2/26: Penis implants
- A61F 5/41: Devices for promoting penis erection
- A61B 2017/00778: {Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence)}
- A61B 2017/00867: {shape memory effect}
- A61B 2017/0406: {Pledgets}
- A61B 2017/0409: {Instruments for applying suture anchors}
- A61B 2017/0417: {T-fasteners}
- A61B 2017/0419: {H-fasteners}
- A61B 2017/0443: {the shaft being resilient and having a coiled or helical shape in the released state}
- A61B 2017/0464: {for soft tissue}
- A61B 2017/06052: {Needle-suture combinations in which a suture is extending inside a hollow tubular needle, e.g. over the entire length of the needle}
- A61B 2017/06171: {helically or spirally coiled}
- A61B 2017/0649: {Coils or spirals}
- A61F 2/2442: {Annuloplasty rings or inserts for correcting the valve shape; Implants for improving the function of a native heart valve}
- A61F 2/2475: {Venous valves}
- A61F 2002/068: {Modifying the blood flow model, e.g. by diffuser or deflector}
- A61F 2220/0008: Fixation appliances for connecting prostheses to the body
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

Veins and other blood vessels may be reshaped by introducing an implant through the vessel walls with anchors positioned on opposite sides of the wall. The anchors typically include an elongate body having coils or other anchors formed therein. The implants may be delivered percutaneously using a cannula which can hold the anchor externally or internally. The methods and devices are useful in treating a dorsal vein to reduce blood flow in patients suffering from erectile dysfunction.

## Claims

### Claim 1

A method for inhibiting blood flow through a vein, said method comprising
penetrating a cannula carrying an implant consisting of an elastic elongate member having a distal end pre-shaped into a coiled distal anchor and a proximal end pre-shaped into a coiled proximal anchor inwardly through a proximal location in a wall of the vein and outwardly through a distal location in the wall of the vein, wherein the implant is constrained in a coiled configuration over an exterior of a distal portion of the cannula while being penetrated;
releasing the distal anchor of the implant from constraint after the distal anchor has advanced beyond the distal location in the wall of the vein to allow the distal anchor to coil over an exterior surface of the wall adjacent to the distal location;
pulling back on the cannula to position the proximal anchor over the proximal location in the wall of the vein;
releasing the proximal end of the implant from constraint to allow the proximal anchor to coil over the exterior surface of the wall adjacent to the proximal location;
wherein the implant collapses or otherwise reconfigures to engage the anchors of the implant against opposed outer surfaces of the vessel wall and to compress the walls of the vein to reshape a lumen of the vein between the first and second location to inhibit blood flow.

### Claim 2 (depends on 1)

A method as in claim 1, wherein the proximal anchor of the implant is released from constraint after the distal anchor has been released over the distal position while the elongate member remains anchored at its distal end.

### Claim 3 (depends on 1)

A method as in claim 1, wherein the implant is anchored in a dorsal vein to treat a patient suffering from erectile dysfunction.

### Claim 4 (depends on 1)

A method as in claim 1, further comprising drawing the implant proximally to pull the distal anchor against the wall to at least partially collapse the wall after the distal anchor has been released and before the proximal end of the implant has been released.

### Claim 5

An implant delivery system for inhibiting blood flow through a vein, said system comprising:
a delivery cannula having an exterior surface and configured to penetrate opposite walls of the vein;
an elastic elongate member consisting of a single wire body coiled over a distal portion of the exterior of the delivery cannula and having a distal end pre-shaped to assume a coiled anchor configuration when released from the exterior surface of the cannula and a proximal end pre-shaped to assume a coiled anchor configuration when released from the exterior surface of the cannula, wherein distal and proximal ends when in their anchor configurations are configured to press against the opposite walls of the vein to control the distance between the opposite walls of the vein when the elastic elongate member is implanted in the vein with each anchor on an exterior surface of a wall of the vein.

### Claim 6 (depends on 5)

An implant delivery system as in claim 5, wherein the cannula comprises an inner needle and an outer mandrel, wherein the distal end of the elongate member is removably secured to the needle and the proximal end of the implant is removably secured to the mandrel so that rotation of the needle relative to the mandrel in a first direction coils the elongate member more tightly over the cannula and rotation of the needle in an opposite direction releases the elongate member from the cannula.