# US 10,499,888 B2 · Tissue sample flushing system for biopsy device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,499,888 B2 - Document ID: US10499888B2 - Status: Granted - Kind: B2 - Application number: 15/255,579 - Filed: 2016-09-02 - Published: 2016-12-22 - Granted: 2019-12-10 - Earliest claimed: 2004-07-09 - Assignees: Bard Peripheral Vascular, Inc. - Applicants: Bard Peripheral Vascular, Inc. - Inventors: Martin Bondo Jorgensen; Karsten Videbaek - Web page: https://patentgrep.com/patent/US10499888B2 ## CPC - A61B 10/0275: {with sample notch, e.g. on the side of inner stylet} - A61B 10/0096: {Casings for storing test samples (A61B10/0038, A61B10/0045 take precedence; preservation of living parts of the human or animal body A01N1/10; containers for retaining a material to be analysed B01L3/50; containers for enzymology or microbiology C12M1/16; swab-sampler being part of enzymology or microbiology container C12M1/30)} - A61B 10/0266: {means for severing sample} - A61B 10/0283: {with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe (A61B10/025, A61B10/0266 take precedence)} - A61B 2010/0208: {Biopsy devices with actuators, e.g. with triggered spring mechanisms} - A61B 2010/0225: {for taking multiple samples} - A61B 2217/002: Auxiliary appliance - A61B 2560/0475: Special features of memory means, e.g. removable memory cards - G01N 2001/315: {Basket-type carriers for tissues} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A biopsy device includes a sample-receiving device with a cavity configured to receive at least one tissue sample. The sample-receiving device is movable between a first position and a second position. A liquid supply unit is configured to supply a flushing liquid. The liquid supply unit is operatively connected to the cavity of the sample-receiving device when the sample-receiving device is in the second position, and the liquid supply unit is disconnected from the cavity of the sample-receiving device when the sample-receiving device is not in the second position. ## Claims ### Claim 1 A biopsy device, comprising: a sample-receiving device with a cavity configured to receive at least one tissue sample, the sample-receiving device being movable between a first position and a second position; and a liquid supply unit having a sample flushing chamber and a pump in fluid communication with the sample flushing chamber, the pump configured to supply a flushing liquid to the sample flushing chamber, the sample flushing chamber having upper and lower openings, wherein when the sample-receiving device is in the second position, the cavity is aligned with the upper and lower openings of the sample flushing chamber to eject the tissue sample from the cavity when the flushing liquid is supplied, and the liquid supply unit being disconnected from the cavity of the sample-receiving device when the sample-receiving device is not in the second position. ### Claim 2 (depends on 1) The biopsy device of claim 1, wherein the pump is a peristaltic pump that is in fluid communication with the cavity of the sample-receiving device when the sample-receiving device is in the second position. ### Claim 3 (depends on 1) The biopsy device of claim 1, further comprising a control system and a transport device to move the sample-receiving device between the first position and the second position, the control system configured to control movement of the transport device and to arrest the sample-receiving device in the second position, the control system being arranged to automatically detect a distance between the first position and the second position. ### Claim 4 A biopsy device, comprising: a hollow needle having a distal circumferential cutting edge; a sample-receiving device located in the hollow needle and movable relative to the hollow needle between a first position and a second position, the sample-receiving device having a cavity for receiving tissue; a liquid supply unit having a sample flushing chamber and a pump, the pump configured to supply a flushing liquid to the sample flushing chamber, the sample flushing chamber having an upper opening and a lower opening, wherein the liquid supply unit is disconnected from the cavity of the sample-receiving device when the sample-receiving device is in the first position, and wherein when the sample-receiving device is in the second position, the cavity is aligned with the upper opening and the lower opening of the sample flushing chamber to facilitate a tissue sample ejection from the cavity when the flushing liquid is supplied from the pump. ### Claim 5 (depends on 4) The biopsy device of claim 4, wherein the hollow needle, the sample-receiving device, and the liquid supply unit are comprised in a single self-contained hand-held unit. ### Claim 6 (depends on 4) The biopsy device of claim 4, further comprising a handle unit and a transport device that moves the sample-receiving device and the hollow needle, the handle unit having a power source and a motorized drive drivably coupled to the transport device. ### Claim 7 (depends on 6) The biopsy device of claim 6, wherein the hollow needle, the sample-receiving device and the sample flushing chamber are releasably secured to the handle unit. ### Claim 8 (depends on 4) The biopsy device of claim 4, wherein the handle unit comprises a liquid container, a hollow transport member, the pump, and a sample-collecting container. ### Claim 9 (depends on 4) The biopsy device of claim 4, further comprising a sample-collecting container defining an opening for receiving a tissue sample ejected from the cavity, wherein the opening of the sample-collecting container is in fluidic communication with the cavity of the sample-receiving device when the sample-receiving device is in the second position. ### Claim 10 (depends on 4) The biopsy device of claim 4, comprising: a sample-collecting container having a plurality of receptacles for respectively receiving individual tissue samples; and an indexing mechanism for changing the relative position of each of the plurality of receptacles relative to the sample-receiving device. ### Claim 11 (depends on 4) The biopsy device of claim 4, further comprising a sample-collecting container, wherein the sample flushing chamber being interposed between the liquid container and the sample-collecting container, and the sample-receiving device being configured such that a flushing fluid is supplied by the pump to the cavity via the flushing chamber to transport a tissue sample from the cavity to the sample-collecting container. ### Claim 12 (depends on 11) The biopsy device of claim 11, wherein the sample-collecting container has a plurality of receptacles for respectively receiving individual tissue samples, and further comprising an indexing device for changing the relative position of the receptacles relative to the sample-receiving device, so that different tissue samples harvested at different times are delivered into separate receptacles of the sample-collecting container. ### Claim 13 (depends on 4) The biopsy device of claim 4, further comprising: a first user-operable firing mechanism configured to longitudinally displace both the hollow needle and the sample-receiving device in a distal direction; and a second user-operable firing mechanism configured to longitudinally displace the hollow needle relative to the sample-receiving device. ### Claim 14 (depends on 4) The biopsy device of claim 4, further comprising a control system and a transport device that moves the sample-receiving device and the hollow needle, the control system configured to control movement of the transport device and to arrest the sample-receiving device in the second position, the control system being arranged to automatically detect a distance between the first position and the second position. ### Claim 15 A hand-held biopsy device, comprising: a hollow needle with a distal end portion having a cutting edge; a sample-receiving device having a cavity for receiving at least one severed tissue sample, the sample-receiving device being received in the hollow needle, the hollow needle configured to be moved relative to the sample-receiving device; a transport device configured to move the sample-receiving device in the hollow needle between an extended position and a retracted position; and a liquid supply unit having a sample flushing chamber and a pump in fluid communication with the sample flushing chamber, the pump being configured to supply a flushing liquid to the sample flushing chamber, the sample flushing chamber having an upper opening and a lower opening, wherein the cavity is aligned with the upper opening and the lower opening of the sample flushing chamber to facilitate a tissue sample ejection by a flushing liquid supplied by the pump only when the sample-receiving device is positioned at the retracted position. ### Claim 16 (depends on 15) The biopsy device of claim 15, the liquid supply unit including a liquid container and a sample-collecting container, wherein when the sample-receiving device is in the retracted position, the cavity is radially aligned with each of the sample flushing chamber and the sample-collecting container, with the cavity being interposed between the liquid container and the sample-collecting container, and configured such that the flushing fluid is supplied by the pump to the cavity via the sample flushing chamber to transport the at least one tissue sample from the cavity to the sample-collecting container. ### Claim 17 (depends on 15) The biopsy device of claim 15, further comprising: a first user-operable firing mechanism configured to longitudinally displace both the hollow needle and the sample-receiving device in a distal direction; and a second user-operable firing mechanism configured to longitudinally displace the hollow needle relative to the sample-receiving device. ### Claim 18 (depends on 17) The biopsy device of claim 17, wherein the hollow needle, the sample-receiving device, transport device, the liquid supply unit, the first user-operable firing mechanism, and the second user-operable firing mechanism are comprised in a single self-contained hand-held unit.