# US 10,499,826 B2 · Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,499,826 B2 - Document ID: US10499826B2 - Status: Granted - Kind: B2 - Application number: 15/725,128 - Filed: 2017-10-04 - Published: 2018-06-07 - Granted: 2019-12-10 - Earliest claimed: 2013-05-07 - Assignees: St. Jude Medical, Atrial Fibrillation Division, Inc. - Applicants: St. Jude Medical, Atrial Fibrillation Division, Inc. - Inventors: Ram K. Balachandran; D. Curtis Deno - Web page: https://patentgrep.com/patent/US10499826B2 ## CPC - A61B 5/287: Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS] - A61B 5/061: {Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body (A61B1/00158 takes precedence)} - A61B 5/349: Detecting specific parameters of the electrocardiograph cycle - A61B 5/367: Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping - A61B 5/7203: {for noise prevention, reduction or removal} - A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)} - A61B 34/20: Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis - A61B 5/062: {using magnetic field} - A61B 5/7239: {using differentiation including higher order derivatives} - A61B 2017/00039: {Electric or electromagnetic phenomena other than conductivity, e.g. capacity, inductivity, Hall effect} - A61B 2017/00044: {Sensing electrocardiography, i.e. ECG} - A61B 2017/00053: {Mapping} - A61B 2018/00577: {Ablation} - A61B 2018/00839: {Bioelectrical parameters, e.g. ECG, EEG} - A61B 2034/2051: {Electromagnetic tracking systems} - A61B 2034/2053: {Tracking an applied voltage gradient} - A61B 2218/002: Irrigation - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A system and method are provided for determining electrophysiological data. The system comprises an electronic control unit that is configured to receive electrical signals from a set of electrodes, receive position and orientation data for the set of electrodes from a mapping system, compensate for position and orientation artifacts of the set of electrodes, compose cliques of a subset of neighboring electrodes in the set of electrodes, determine catheter orientation independent information of a target tissue, and output the orientation independent information to a display. The method comprising receiving electrogram data for a set of electrodes (80), compensating for artifacts in sensor positions in the mapping system (81), resolving the bipolar signals into a 3D vector electrogram in the mapping system coordinates (82), manipulating observed unipolar voltage signals and the tangent component of the e-field to estimate the conduction velocity vector (83), and outputting the catheter orientation independent information (84). ## Claims ### Claim 1 A system for determining electrophysiological data, comprising: an electronic control unit configured to: receive electrogram data for a set of electrodes, compose a clique of at least three neighboring electrodes from the set of electrodes, wherein the electrogram data comprises a plurality of signals taken from the at least three neighboring electrodes in the clique; receive position and orientation information for the set of electrodes from a mapping system; derive an E-field from the plurality of signals of the clique; determine catheter orientation independent information of a tissue based on the electrogram data and position and orientation information from the set of electrodes, wherein the catheter orientation independent information comprises a local tangent E-field and an orthogonal unit vector in the direction along which the wavefront is propagating (â); and output the orientation independent information to a user or process. ### Claim 2 (depends on 1) The system according to claim 1, wherein the orientation independent information further comprises at least one of a 2D vector electric field, a 3D vector electric field, a normal electric field, the eccentricity of the tangent electric field loop, derived normal and tangent bipolar electrogram signals, a wavefront conduction velocity, or a unit direction vector. ### Claim 3 (depends on 1) The system according to claim 1, wherein the electronic control unit is further configured to compensate for artifacts in the position and orientation information received from the mapping system. ### Claim 4 (depends on 1) The system according to claim 1, wherein the electronic control unit is further configured to resolve the electrogram data into a 3D vector electrogram in a coordinate system of the mapping system. ### Claim 5 (depends on 1) The system according to claim 1, wherein the catheter orientation independent information further comprises a wavefront conduction velocity and a 2D vector electric field. ### Claim 6 (depends on 1) The system according to claim 1, wherein the electronic control unit is further configured to resolve the electrogram data into a 2D vector electrogram in a coordinate system of the mapping system. ### Claim 7 (depends on 6) The system according to claim 6, wherein the catheter orientation independent information further comprises a conduction velocity magnitude. ### Claim 8 (depends on 1) The system according to claim 1, wherein the plurality of signals comprise unipole signals. ### Claim 9 (depends on 1) The system according to claim 1, wherein the plurality of signals comprise bipolar signals. ### Claim 10 (depends on 1) The system according to claim 1, wherein the plurality of signals are received when the at least three neighboring electrodes in the clique are in contact with a tissue. ### Claim 11 A system for determining electrophysiological data, comprising: an electronic control unit configured to: receive electrical signals from a set of electrodes; receive position and orientation data for the set of electrodes from a mapping system; compensate for position and orientation artifacts of the set of electrodes; compose cliques of a subset of neighboring electrodes in the set of electrodes, wherein each of the cliques comprise at least three electrodes, wherein the electrical signals comprise a plurality of signals taken from the at least three neighboring electrodes in each of the cliques; derive an E-field for a tissue adjacent to each of the cliques from the plurality of signals; determine catheter orientation independent information of a target tissue based on the electrogram data and position and orientation information from the set of electrodes, wherein the catheter orientation independent information comprises a local tangent E-field and an orthogonal unit vector in the direction along which the wavefront is propagating (â); and output the orientation independent information to a display. ### Claim 12 (depends on 11) The system according to claim 11, wherein the orientation independent information further comprises a local estimate of the conduction velocity vector. ### Claim 13 (depends on 11) The system according to claim 11, wherein the plurality of signals are received when the at least three neighboring electrodes in the clique are in contact with a tissue. ### Claim 14 (depends on 11) The system according to claim 11, wherein the plurality of signals comprise bipolar signals. ### Claim 15 A method of determining electrophysiological data, comprising: receiving electrogram data for a set of electrodes, composing a clique of at least three neighboring electrodes from the set of electrodes, wherein the electrogram data comprises a plurality of signals taken from the at least three neighboring electrodes in the clique; receiving position and orientation information for the set of electrodes from a mapping system; deriving an E-field from the plurality of signals; determining catheter orientation independent information of a tissue based on the electrogram data and position and orientation information from the set of electrodes, wherein the catheter orientation independent information comprises a local tangent E-field and an orthogonal unit vector in the direction along which the wavefront is propagating (â); and outputting the orientation independent information to a user or process. ### Claim 16 (depends on 15) The method according to claim 15, wherein the orientation independent information further comprises at least one of a 2D vector electric field, a 3D vector electric field, a normal electric field, the eccentricity of the tangent electric field loop, derived normal and tangent bipolar electrogram signals, a wavefront conduction velocity, or a unit direction vector. ### Claim 17 (depends on 15) The method according to claim 15 further comprising compensating for artifacts in the position and orientation information received from the mapping system. ### Claim 18 (depends on 15) The method according to claim 15, wherein the plurality of signals comprise bipolar signals. ### Claim 19 (depends on 15) The method according to claim 15, wherein the orientation independent information further comprises a local estimate of the conduction velocity vector. ### Claim 20 (depends on 19) The method according to claim 19, wherein the plurality of signals are received when the at least three neighboring electrodes in the clique are in contact with a tissue.