# US 10,499,813 B2 · Methods, systems and apparatus for temporal calibration of an intravascular imaging system

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,499,813 B2
- Document ID: US10499813B2
- Status: Granted
- Kind: B2
- Application number: 14/484,832
- Filed: 2014-09-12
- Published: 2016-03-17
- Granted: 2019-12-10
- Earliest claimed: 2014-09-12
- Assignees: LightLab Imaging, Inc.
- Applicants: LightLab Imaging, Inc.
- Inventors: Desmond Adler
- Web page: https://patentgrep.com/patent/US10499813B2

## CPC

- A61B 5/0035: {adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography}
- A61B 5/0066: {Optical coherence imaging}
- A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)}
- A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance}
- A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography}
- A61B 6/5205: {involving processing of raw data to produce diagnostic data}
- A61B 6/5247: {combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound}
- A61B 6/545: {involving automatic set-up of acquisition parameters}
- A61B 6/58: Testing, adjusting or calibrating thereof
- A61B 6/582: {Calibration}
- A61B 6/488: {involving pre-scan acquisition}
- A61B 8/12: in body cavities or body tracts, e.g. by using catheters
- A61B 2560/0223: of calibration, e.g. protocols for calibrating sensors
- A61B 2560/0238: Means for recording calibration data
- A61B 2576/02: specially adapted for a particular organ or body part
- G16H 30/40: for processing medical images, e.g. editing
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

In part, the disclosure relates to systems for imaging a blood vessel using intravascular image data and extravascular image data and methods to calibrate such systems. In one embodiment, multiple calibration trials are performed to determine a plurality of time lag values. A minimum time lag value is used to align intravascular image data and extravascular time lag data in one embodiment.

## Claims

### Claim 1

A calibration system comprising:
an optical coherence tomography (OCT) probe comprising a marker, wherein the probe is configured to collect OCT data, wherein the probe is disposed within an imaging zone of an angiography system;
an optical coherence tomography data processing system comprising
a computing device comprising a processor, the computing device programmed to generate frames of OCT images based upon received intravascular probe signals and to receive angiography data comprising angiography frames, the processor configured to cause the computing device to determine a minimum time delay between an initial OCT frame and an initial angiography frame from a set of time delays; and
one or more memory devices in electrical communication with the computing device; and
a controller programmed to initiate a plurality of pullbacks of the OCT probe, in response to a control signal, during which OCT data is collected, and transmit each pullback initiation time to the one or more memory devices.

### Claim 2 (depends on 1)

The system of claim 1 wherein the computing device comprises a calibration method stored in the one or more memory devices as instructions to cause the computing device to determine an initial frame of the OCT probe for each pullback.

### Claim 3 (depends on 1)

The system of claim 1 wherein the computing device comprises a calibration method stored in the one or more memory devices as instructions to cause the computing device to determine an initial angiography frame that corresponds to an initial frame of OCT probe pullback.

### Claim 4 (depends on 1)

The system of claim 1 wherein the computing device comprises a calibration method stored in the one or more memory devices as instructions to cause the computing device to determine a time delay between an initial OCT frame and an initial angiography frame.

### Claim 5 (depends on 4)

The system of claim 4 wherein the calibration method further comprises instructions to cause the computing device to align OCT frames and angiography frames using the time delay.

### Claim 6 (depends on 1)

The system of claim 1 further comprising a display in electrical communication with the optical coherence data processing system, wherein the computing device is programmed to align one or more OCT frames and one or more angiography frames using the minimum time delay and display one or more of such aligned frames.

### Claim 7 (depends on 1)

The system of claim 1 wherein a frame rate of the optical coherence tomography data processing system is greater than a frame rate of the angiography system.

### Claim 8 (depends on 1)

The system of claim 1 wherein the computing device is programmed to track pixel changes in angiography frames to identify marker movement.

### Claim 9 (depends on 8)

The system of claim 8 wherein the computing device is programmed to use to marker movement to determine an initial angiography frame.

### Claim 10 (depends on 8)

The system of claim 8 wherein the computing device is programmed to align an OCT frame with an angiography frame in response to tracked marker positions.

### Claim 11 (depends on 1)

The system of claim 1 wherein the computing device is programmed to store a time an OCT pullback is initiated in the one or more memory devices.

### Claim 12 (depends on 1)

The system of claim 1 wherein the computing device is programmed to determine a time delay between an angiography frame and an OCT frame.