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US 10,494,634 B2Granted
Factor XIa-specific aptamers
AssigneeCanadian Blood Services
InventorsWilliam Peter Sheffield, David Apraku Donkor
Life of this patent
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Abstract
The present disclosure concerns aptamers of formula (I) capable of specifically binding to Factor XIa. The aptamers can be used to prevent, treat or alleviate the symptoms of thrombosis. The aptamers can also be used to detect Factor XIa in a sample and/or purify Factor XIa from a sample. The aptamers can further be used to identity putative therapeutic agents for the prevention, treatment or alleviation of symptoms associated with thrombosis.
Claims14
An aptamer having the structure of formula (I):
- (I)
- 5′-5W-C-3W-3′
- wherein:
- “-” refers to a nucleotide bond;
- 5W has the following first nucleic acid sequence:
- (SEQ ID NO:
- 66)
- N17N18N19N20N21N22N23N24N71N26N27N28AN29TN30TA;
- C has nucleic acid sequence of SEQ ID NO:
- 24, 30, 32, 35, 36 or 69;
- 3W can be present or absent and when present has the following third nucleic acid sequence:
- (SEQ ID NO:
- 67)
- 5′-N31N32N33N34N35N36N37N38N39N40N41-3′;
- and
- the nucleotides at position 14 to 18 (N29TN30TA) of SEQ ID NO:
- 66 are capable of base pairing with the nucleotides at position 33 to 29 of SEQ ID NO:
- 24, 30, 32, 35, 36 or 69.
15 more elements
Dependencies are inferred from the claim text.