Switchable antimicrobial and antifouling carboxybetaine-based hydrogels and elastomers with enhanced mechanical properties
AssigneeThe University of Akron
InventorsGang Cheng, Bin Cao
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Abstract
Various embodiments of the present invention are directed to switchable carboxybetaine-based polymers, hydrogels, and/or elastomers, along with novel related monomers, crosslinkers, and methods. Under acidic conditions, the materials undergo self-cyclization and can catch and kill bacteria. Under neutral/basic conditions, these materials undergo ring-opening and can release killed bacterial cells and resist protein adsorption and bacterial attachment. These smart polymers, hydrogels and elastomers also show excellent mechanical properties making them highly desirable for many biomedical applications.
Claims23
A zwitterionic composition having anti-fouling and antimicrobial properties comprising:
- a polymer backbone formed from monomers selected from the group consisting of acrylates, methacrylates, acrylamides, methacrylamides, vinyl alcohols, serines and combinations thereof;
- one or more zwitterionic moieties chemically bonded to said polymer backbone, said zwitterionic moieties further comprising a carboxybetaine group having at least one ethanol, propanol, butanol or pentanol group bonded to the nitrogen atom of said carboxybetaine group;
- and
- a crosslinking compound.
A carboxybetaine-based composition having anti-fouling and antimicrobial properties comprising:
- a zwitterionic polymer selected from the group consisting of poly(2-((2-hydroxyethyl)(2-methacrylamidoethyl)(methyl)ammonio)acetate), poly(3-((2-hydroxyethyl)(2-methacrylamidoethyl)(methyl)ammonio)propanoate), poly(2-((2-hydroxyethyl)(2-(methacryloyloxy)ethyl)(methyl)ammonio)acetate) and poly(2-(bis(2-hydroxyethyl)(2-(methacryloyloxy)ethyl)ammonio)acetate) and combinations thereof;
- and
- a crosslinker.
Dependencies are inferred from the claim text.