Near-IR glucose sensors
AssigneeProfusa, Inc.
InventorsSoya Gamsey, Viachaslau Bernat, Alex Kutyavin, Jacob William Clary, Sulolit Pradhan
Life of this patent
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Abstract
The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.
Claims30
A compound of Formula III:
- or a tautomer or a salt thereof,
- wherein the dotted lines at each occurrence independently denote a bond or absence of a bond;
- and when the dotted line connecting R1 and O is a bond, R1 is CX1X2 and R15 is absent;
- and when the dotted line connecting R1 and O is absence of a bond, R15 is H or C1-C6 alkyl, and R1, at each occurrence, is H, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C2-C10 heteroalkyl, a polymerizable moiety, an NIR dye moiety, an electron-withdrawing group, or an electron-donating group;
- X1 and X2 are independently H or C1-C6 alkyl;
- R2 is H or C1-C6 alkyl;
- R3, R4, R5, R6, R7, R8, R11, R12, and R14 are independently H, C1-C6 alkyl, polymerizable moiety, electron-withdrawing group, or electron-donating group;
- R9 and R10 are independently H, C1-C6 alkyl, polymerizable moiety, or NIR dye;
- L1 and L3 are independently a bond, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, optionally substituted C2-C20 heteroalkyl, or (CH2CH2O)pCH2CH2, wherein p is 2, 3, 4, or 5 or;
- L2 is a bond, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, optionally substituted C2-C20 heteroalkyl, —O—, optionally substituted —CH2C6H4O—, amido, amino, or optionally substituted C6-C10 arylene, or optionally substituted C2-C10 heteroarylene;
- R13 is
- Y1 is selected from —O—, —P(O)R′, —SiR′R″, and —NR′, wherein R′ and R″ are independently H or C1-C6 alkyl;
- R20 and R21 are independently —H, C1-C6 alkyl or R21 and R20, together with the nitrogen atom to which they are attached, form a form a 6- or 5-membered ring optionally substituted with a polymerizable moiety;
- R23 and R24 are independently —H, C1-C6 alkyl, or R23 and R24, together with the nitrogen atom to which they are attached, form a form a 6- or 5-membered ring optionally substituted with a polymerizable moiety;
- R22 and R25 are independently —H, C1-C6 alkyl, or R21 and R22, together with the atoms to which they are attached, form a 6- or 5-membered ring, or R24 and R25, together with the atoms to which they are attached, form a 6- or 5-membered ring;
- R26 and R27 are independently —H, C1-C6 alkyl, or R26 and R20, together with the atoms to which they are attached, form a 6- or 5-membered ring, or R27 and R23, together with the atoms to which they are attached, form a 6- or 5-membered ring;
- and
- the compound comprises one or more polymerizable moieties.
Dependencies are inferred from the claim text.