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US 10,493,143 B2Granted
Sexually transmitted disease vaccines
AssigneeModernaTX, Inc.
InventorsGiuseppe Ciaramella, Sunny Himansu
Life of this patent
Estimating the term…
Abstract
The disclosure relates to sexually transmitted disease ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
Claims19
A human papillomavirus (HPV) vaccine, comprising:
- a messenger ribonucleic acid (mRNA) polynucleotide comprising an open reading frame encoding a HPV protein selected from HPV E1 protein, HPV E2 protein, HPV E4 protein, HPV E5 protein, HPV E6 protein, HPV E7 protein, HPV L1 protein, and HPV L2 protein formulated in a lipid nanoparticle that comprises a molar ratio of 20-60% cationic lipid, 0.5-15% PEG-modified lipid, 25-55% sterol, and 5-25% non-cationic lipid, wherein the mRNA polynucleotide is not a self-replicating RNA, and the cationic lipid comprises a Compound 25 lipid:
Dependencies are inferred from the claim text.