DPEP-1 binding compositions and methods of use
AssigneeArch Biopartners, Inc.
InventorsStephen Mark Robbins, Donna Lorraine Senger, Jennifer Joy Rahn, Arthur Wing Sze Lau, Daniel Abraham Muruve, Saurav Roy Choudhury, Liane Babes, Paul Kubes
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Abstract
Pharmaceutical compositions and methods of their use are provided for reducing inflammation in a subject, blocking leukocyte recruitment, inhibiting tumor metastasis, treating sepsis and preventing/reducing acute kidney injury.
Claims7
A method for treating ischemia-reperfusion injury in a subject in need thereof, comprising administering an effective amount of cilastatin that binds to dipeptidase 1 (DPEP-1) to the subject, in the absence of an antibiotic or nephrotoxic compound thereby reducing ischemia-reperfusion injury.
Dependencies are inferred from the claim text.