Methods of inhibiting the virulence of a pathogen with an oxidized tannin to treat a gastrointestinal spasm
AssigneeLiveLeaf, Inc.
InventorsAlexander L Huang, Gin Wu
Life of this patent
Estimating the term…
Abstract
Methods of inhibiting the virulence of a pathogen to treat a gastrointestinal spasm in a subject, without killing the pathogen, are provided. The methods can include administering an effective amount of a formulation to treat the gastrointestinal spasm, the formulation having a tannin combined with a hydroxyl radical in a pharmaceutically acceptable excipient as a binding pair, the tannin releasing in an oxidized state from the hydrogen donor after oral administration of the formulation in the subject; wherein, the composition at least inhibits a gastrointestinal spasm in the subject when compared to a second subject in a control group in which the composition was not administered.
Claims21
A method of inhibiting the virulence of a pathogen in a subject to treat a gastrointestinal spasm, the method comprising:
- orally administering an effective amount of a formulation to treat a gastrointestinal spasm in the subject, the formulation having a binding pair in a pharmaceutically acceptable excipient;
- wherein, the binding pair is created by a process comprising:
- selecting a water soluble tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
- and,
- oxidizing the tannin with a hydroxyl radical, the oxidizing including combining the tannin with the hydroxyl radical at a weight ratio ranging from about 1:1000 to about 10:1 to oxidize the tannin and form the binding pair having the oxidized tannin releasably bound to the hydroxyl radical;
- wherein,
- the formulation inhibits the virulence of a pathogen;
- the gastrointestinal spasm is a symptom of a condition selected from the group consisting of inflammatory bowel syndrome, Crohn's disease, ulcerative colitis, diverticulitis, colorectal cancer, stress, malnutrition, necrotic enteritis, drug side-effects, chemotherapy, radiation therapy, and gastroesophageal reflux disease;
- and,
- the formulation at least inhibits the gastrointestinal spasm when compared to a second subject in a control group in which the formulation was not administered.
A method of inhibiting the virulence of a pathogen in a subject to treat a gastrointestinal spasm, the method comprising:
- administering an effective amount of a formulation to treat a gastrointestinal spasm in the subject, the formulation having a water soluble tannin combined with a hydroxyl radical to create a binding pair prior to the administering;
- wherein, the binding pair is created by a process comprising:
- selecting a water-soluble tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
- oxidizing the tannin with a hydroxyl radical, the oxidizing including combining the tannin with the hydroxyl radical at a weight ratio ranging from about 1:1000 to about 10:1 to form the binding pair having the oxidized tannin releasably bound to the hydroxyl radical;
- wherein,
- the formulation at least inhibits the virulence of a pathogen;
- the gastrointestinal spasm is a symptom of a condition selected from the group consisting of inflammatory bowel syndrome, Crohn's disease, ulcerative colitis, diverticulitis, colorectal cancer, stress, malnutrition, necrotic enteritis, drug side-effects, chemotherapy, radiation therapy, and gastroesophageal reflux disease;
- and,
- the formulation at least inhibits the gastrointestinal spasm when compared to a second subject in a control group in which the formulation was not administered.
Dependencies are inferred from the claim text.