Compositions containing arsenic and their use in methods of treatment
AssigneeEupharma Pty Ltd
InventorMalvin Eutick
Life of this patent
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Abstract
A pharmaceutical composition is provided comprising a highly soluble arsenic carbonate and/or bicarbonate compound and which is useful in the treatment of a variety of cancers, including acute promyelocytic leukaemia. The arsenic carbonate and/or bicarbonate salt acts as a solid, and so orally deliverable, improved bioequivalent delivery form of arsenic trioxide IV solutions.
Claims19
A pharmaceutical composition comprising an effective amount of arsenic carbonate and/or arsenic bicarbonate and a pharmaceutically acceptable excipient.
A method of treating a cancer in a patient including the step of orally administering a pharmaceutical composition comprising an effective amount of an arsenic carbonate and/or arsenic bicarbonate and a pharmaceutically acceptable excipient to the patient to thereby treat the cancer.
A process for producing a pharmaceutical composition comprising an effective amount of an arsenic carbonate and/or arsenic bicarbonate in solid form and a pharmaceutically acceptable excipient for oral delivery to a patient in need of cancer therapy including the steps of:
- (a) solubilizing arsenic trioxide in a strongly basic solution;
- (b) contacting the strongly basic solution with a carbonate and/or bicarbonate compound;
- (c) removing the solvent from the strongly basic solution containing dissolved arsenic carbonate and/or bicarbonate compound to produce the arsenic carbonate and/or bicarbonate in solid form;
- and
- (d) adding one or more of a drying agent, dispersant or disintegrant to the arsenic
- carbonate and/or bicarbonate in solid form after the solvent has been removed,
- to thereby produce the pharmaceutical composition comprising an effective amount of arsenic carbonate and/or bicarbonate in solid form and a pharmaceutically acceptable excipient.
A method of delivering a therapeutically effective amount of an arsenic ion to a patient comprising the step of administering to the patient a pharmaceutical composition comprising an effective amount of an arsenic carbonate and/or arsenic bicarbonate and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.