Combination comprising immunostimulatory oligonucleotides

A method of treating cancer, comprising administering, to a subject in need thereof, a combination comprising the components of groups (a) and (b):

• (a) a first group comprising an antibody binding to at least one of the molecules selected from the group consisting of PD1, PD-L1 and CTLA-4 for affecting their function as T-cell regulators;
• and
• (b) a second group comprising a non-coding sequence of deoxyribonucleic acids comprising at least one sequence motif N1N2CGN3N4, wherein N is a nucleotide comprising A, C, T, or G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxythymidine,
• wherein the non-coding sequence of deoxyribonucleic acids is either linear open-chained on both sides, linear open-chained on one side of a double stranded part with a single stranded hairpin on the respective other side of the double strand, or a dumbbell-shaped partially single-stranded covalently closed chain of deoxyribonucleic acids, and
• wherein the linear open-chained non-coding sequence of deoxyribonucleic acids comprises at least one nucleotide in L-conformation.