Certain steroids and methods for using the same in the treatment of cancer

A compound of Formula I:

• or pharmaceutically acceptable salt thereof, wherein:
• R1, R2, R3, R4, R5, R6, R9, R10, R11 and R12 are independently selected from the group consisting of hydrogen, hydroxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted aminocarbonyloxy, optionally substituted acyloxy, optionally substituted alkoxycarbonyloxy, and optionally substituted amino;
• or
• R1 and R2, or R5 and R6, or R7 and R8, or R9 and R10, or R11 and R12 mutually independently, together in each case denote an oxo group (═O);
• or
• R4 and R5 may optionally be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring;
• R7 is selected from the group consisting of hydrogen, hydroxy, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted aminocarbonyloxy, optionally substituted acyloxy, optionally substituted alkoxycarbonyloxy, and optionally substituted amino;
• R8 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, and optionally substituted alkynyl;
• R13 is selected from the group consisting of hydrogen, optionally substituted alkyl, and formyl;
• R14 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• R15 is selected from the group consisting of —CONR17R18, —C(NR19)NR17R18, —C(NCN)NR17R18, —SO2R16, and —SO2NR17R18;
• R16 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• R17is selected from the group consisting of optionally alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl and optionally substituated heteroaryl;
• R18 and R19 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• W1 is:
• Y is selected from the group consisting of O and NR21;
• R20 is selected from the group consisting of cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbaminodoyl, and optionally substituted alkynyl;
• R21 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
• W2 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, and optionally substituted alkynyl;
• m is selected from 0, 1, 2, and 3;
• n, p, and q are independently selected from 0 and 1;
• and
• each independently represents a single bond or a double bond.