Fluid transfer from digital microfluidic device
AssigneesDH Technologies Development Pte. Ltd., University of Toronto
InventorsJohn Lawrence Campbell, Kihwan Choi, Yves LeBlanc, Chang Liu, Aaron Wheeler
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Abstract
Methods and systems for processing fluids utilizing a digital microfluidic device and transferring droplets from the digital microfluidic device to a downstream analyzer are described herein. Methods and systems in accordance with the present teachings can allow for the withdrawal of fluid from a digital microfluidic device, and can in some aspects enable the integration of a digital microfluidic device as a direct, in-line sample processing platform from which a droplet can be transferred to a downstream analyzer.
Claims11
A method of processing a sample comprising:
- disposing a sample droplet between a top plate and a bottom plate of a digital microfluidic device, one of the top plate and bottom plate having a sampling hole, and
- pre-filling the sampling hole with an aqueous solution from a needle or pipette to form an extraction droplet in the sampling hole,
- contacting the sample droplet and the extraction droplet with one another so as to form a merged droplet at least partially disposed in the sampling hole, wherein the needle or pipette removes at least a portion of the merged droplet by aspiration from the digital microfluidic device via the sampling hole.
Dependencies are inferred from the claim text.