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US 10,485,856 B2Granted
Carbon nanotube compositions and methods of use thereof
AssigneeYale University
InventorsTarek M. Fahmy, Lisa D. Pfefferle, Gary L. Haller, Tarek R. Fadel
Life of this patent
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Abstract
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or antigens. The CNT compositions function as artificial antigen-presenting cells (aAPCs) or as modular vaccines. The disclosed CNT aAPCs are efficient at activating T cells and may be used to activate T cells ex vivo or in vivo for adoptive or active immunotherapy.
Claims19
A method for making a formulation for adoptive immunotherapy comprising
- contacting regulatory T cells (Treg) isolated from a subject with carbon nanotube bundles comprising acid washed carbon nanotubes, the nanotubes having bound to or present on the surface one or more T cell receptor activators selected from the group consisting of antigens bound to MHC molecules and antibodies or fragments thereof that crosslink the T cell receptor/CD3 complex, one or more T cell costimulatory or T cell adhesion molecules, and polymeric nanoparticles comprising a cytokine encapsulated therein,
- for an effective amount of time to activate, expand, or activate and expand the Treg cells.
Dependencies are inferred from the claim text.