# US 10,482,680 B2 · Ablation therapy control based on multi-parameter graphical maps

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- Number: US 10,482,680 B2
- Document ID: US10482680B2
- Status: Granted
- Kind: B2
- Application number: 14/158,320
- Filed: 2014-01-17
- Published: 2014-07-17
- Granted: 2019-11-19
- Earliest claimed: 2013-01-17
- Assignees: Cardioinsight Technologies, Inc.
- Applicants: Cardioinsight Technologies, Inc.
- Inventors: Qingguo Zeng; Charulatha Ramanathan; Venkatesh Vasudevan; Remi Dubois; Ping Jia
- Web page: https://patentgrep.com/patent/US10482680B2

## CPC

- G06T 19/20: Editing of three-dimensional [3D] images, e.g. changing shapes or colours, aligning objects or positioning parts
- A61B 5/333: Recording apparatus specially adapted therefor
- A61B 5/339: Displays specially adapted therefor
- A61B 5/7289: {Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition}
- A61B 5/742: {using visual displays (displays for heart-related electrical signals, e.g. ECG, A61B5/339)}
- A61B 5/743: {Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots}
- G06T 7/0012: {Biomedical image inspection}
- G06T 11/10: Texturing; Colouring; Generation of textures or colours (retouching, inpainting or scratch removal G06T5/77)
- G09B 23/30: Anatomical models {(G09B23/281 - G09B23/288 take precedence)}
- A61B 5/7221: {Determining signal validity, reliability or quality (preventing, reducing or removing noise induced by motion artefacts A61B5/7207; noise originating from a therapeutic or surgical apparatus A61B5/7217)}
- A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)}
- A61B 2017/00053: {Mapping}
- A61B 2018/00351: {Heart}
- A61B 2018/00642: {with feedback, i.e. closed loop control}
- A61B 2018/0072: {Current}
- A61B 2018/00726: {Duty cycle}
- A61B 2018/00732: {Frequency}
- A61B 2018/00767: {Voltage}
- A61B 2018/00839: {Bioelectrical parameters, e.g. ECG, EEG}
- A61B 2018/0212: {using an instrument inserted into a body lumen, e.g. catheter}
- A61B 2090/376: {using X-rays, e.g. fluoroscopy}
- A61B 2562/046: in a matrix array
- A61N 1/362: Heart stimulators (heart defibrillators A61N1/39)
- A61N 7/02: Localised ultrasound hyperthermia
- G06T 2207/10024: Color image
- G06T 2210/41: Medical
- G06T 2219/2012: Colour editing, changing, or manipulating; Use of colour codes
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G09B: EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS (devices for psychotechnics or for testing reaction times A61B5/16; games, sports, amusements A63; projectors, projector screens G03B)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

A map generator can be programmed to generate a multi-parameter graphical map by encoding at least two different physiological parameters for a geometric surface, corresponding to tissue of a patient, using different color components of a multi-dimensional color model such that each of the different physiological parameters is encoded by at least one of the different color components.

## Claims

### Claim 1

A system comprising:
a plurality of sensors configured to measure electrophysiological signals from cardiac tissue associated with a patient;
an ablation catheter configured to deliver an ablative therapy by applying one or more of heating, cooling and high-frequency; and
a computing device coupled to the plurality of sensors, the computing device comprising:
memory storing machine readable instructions and configured to store electroanatomic data; and
at least one processor configured to access the memory and execute the machine readable instructions,
wherein the machine readable instructions are further configured to perform, when executed, a method comprising:
measuring the electrophysiological signals;
storing the electroanatomic data that corresponds to the electrophysiological signals measured by the plurality of sensors;
computing phase data for each of a plurality of points of a geometric surface corresponding to the cardiac tissue based on the electroanatomic data for at least one-time interval;
encoding the phase data to a first color component representing a dimension of a multi-dimensional color model, wherein the multi-dimensional real time model comprises at least two dimensions;
computing magnitude data for each of the plurality of points of the geometric surface corresponding to the cardiac tissue based on the electroanatomic data for at least one-time interval;
encoding the magnitude data to a second color component representing another dimension of the multi-dimensional color model; and
generating the output data corresponding to a multi-parameter graphical map for the geometric surface corresponding to the cardiac tissue of the patient by mapping the phase data to the first color component and the magnitude data to the second color component;
displaying the multi-parameter graphical map for the geometric surface corresponding to the cardiac tissue of the patient;
configuring one or more control parameters for delivering the ablative therapy to the cardiac tissue based on the multi-parameter graphical map;
delivering the ablative therapy to the cardiac tissue according to the one or more control parameters; and
reconfiguring the one or more control parameters intraoperatively during delivery of the ablative therapy based on one or more changes to the output data reflected in the multi-parameter graphical map.

### Claim 2 (depends on 1)

The system of claim 1, the method further comprising normalizing the magnitude data or the phase data to a predetermined scale.

### Claim 3 (depends on 2)

The system of claim 2, the method further comprising adjusting a property of the normalizing in response to a user input.

### Claim 4 (depends on 1)

The system of claim 1, wherein the multi-parameter graphical map is a first graphical map, the method further comprising generating a second graphical map concurrently with the first graphical map, the second graphical map including only one of the phase data or the magnitude data.

### Claim 5 (depends on 1)

The system of claim 1, further comprising control circuitry connected to the ablation catheter, the control circuitry configured to control delivery of the ablative therapy to the cardiac tissue based on the one or more control parameters.

### Claim 6 (depends on 5)

The system of claim 5, further comprising one or more sensors located on the ablation catheter to communicate sensor information back to the control circuitry to which the ablation catheter is connected.

### Claim 7 (depends on 5)

The system of claim 5, wherein the control system is further configured to provide the one or more control parameters based on a position of the ablation catheter relative to the cardiac tissue.