# US 10,482,601 B2 · Evaluation of carotid plaque using contrast enhanced ultrasonic imaging > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,482,601 B2 - Document ID: US10482601B2 - Status: Granted - Kind: B2 - Application number: 16/190,462 - Filed: 2018-11-14 - Published: 2019-03-21 - Granted: 2019-11-19 - Earliest claimed: 2014-01-23 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Michalakis Averkiou; Damianos Christophides; Edward Lam Shang Leen - Web page: https://patentgrep.com/patent/US10482601B2 ## CPC - G06T 7/0016: {involving temporal comparison} - A61B 8/06: Measuring blood flow - A61B 8/4444: {related to the probe} - A61B 8/4494: {characterised by the arrangement of the transducer elements} - A61B 8/461: {Displaying means of special interest} - A61B 8/481: {involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream} - A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)} - G06F 18/22: Matching criteria, e.g. proximity measures - G06T 7/20: Analysis of motion (motion estimation for coding, decoding, compressing or decompressing digital video signals H04N19/43, H04N19/51) - H04N 23/683: {performed by a processor, e.g. controlling the readout of an image memory} - G06T 2207/10132: Ultrasound image - G06T 2207/10136: 3D ultrasound image - G06T 2207/20021: Dividing image into blocks, subimages or windows - G06T 2207/30101: Blood vessel; Artery; Vein; Vascular - G06T 2207/30104: Vascular flow; Blood flow; Perfusion - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G06F: ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N) - H04N: PICTORIAL COMMUNICATION, e.g. TELEVISION ## Abstract An ultrasound system and method are described for acquiring a sequence of ultrasound images of the carotid artery during the delivery of a contrast agent. Plaque in the images is identified and a time-intensity curve is calculated for pixels in the images. The intensity values before and after the arrival of contrast are compared to identify pixels or groups of pixels having perfusion. An anatomical image may be formed showing areas in an image of the plaque of the intensity and presence of perfusion, or the perfusion may be quantified by determining the percentage of pixels in the plaque image which exhibit perfusion. The extent and degree of perfusion is an indicator of the risk of plaque particulates in the blood stream which may lead to stroke-related symptoms. ## Claims ### Claim 1 An ultrasonic diagnostic imaging system for the evaluation of plaque by enhanced ultrasound, the system comprising: an ultrasound imaging probe, wherein the ultrasound probe comprises an array transducer, wherein the array transducer is arranged to acquire a sequence of ultrasound images of a plaque region in a carotid artery; a time intensity curve calculator arranged to form a first plurality of time intensity curves for the plaque region, wherein the plaque region comprises a plurality of pixels, wherein the first plurality of time intensity curves includes a time intensity curve for a portion of the plurality of pixels; a comparator circuit arranged to determine a perfusion, wherein the perfusion is based on a difference of a second plurality of time intensity curves for the plaque region and the first plurality of time intensity curves for the plaque region; and a display arranged to display the perfusion in the plaque region. ### Claim 2 (depends on 1) The ultrasonic diagnostic imaging system of claim 1, further comprising an image processor circuit, wherein the image processor circuit is arranged to produce an anatomical map of the plaque region showing wherein the perfusion is present. ### Claim 3 (depends on 1) The ultrasonic diagnostic imaging system of claim 1, further comprising a perfusion quantifier, wherein the perfusion quantifier is arranged to quantify the percentage of pixels in the plaque region exhibiting the perfusion. ### Claim 4 (depends on 1) The ultrasonic diagnostic imaging system of claim 1, further comprising a frame memory, wherein the frame memory is arranged to store the acquired sequence of ultrasound images. ### Claim 5 (depends on 4) The ultrasonic diagnostic imaging system of claim 4, further comprising an image stabilizer, wherein the image stabilizer is arranged to compensate for frame-to-frame motion. ### Claim 6 (depends on 1) The ultrasonic diagnostic imaging system of claim 1, further comprising a plaque tracer, wherein the plaque tracer is arranged to outline a plaque in a carotid image. ### Claim 7 (depends on 6) The ultrasonic diagnostic imaging system of claim 6, wherein the plaque tracer further comprises a user control of an ultrasound system control panel. ### Claim 8 (depends on 1) The ultrasonic diagnostic imaging system of claim 1, wherein the comparator circuit is arranged to compare pixel intensity values before and after contrast arrival in the plaque region. ### Claim 9 A method of evaluating plaque with enhanced ultrasound, the method comprising: acquiring a sequence of ultrasound images of a carotid artery, wherein the carotid artery has plaque; identifying a plaque region in an ultrasound image of the sequence, wherein the plaque region comprises a plurality of pixels; forming a first time intensity curve for a portion of the plurality of pixels; forming a second time intensity curve after the arrival of contrast comparing the first time intensity curve to the second time intensity curve; identifying, one or more pixels in the image having a perfusion based on the comparison; and displaying the perfusion in the plaque region. ### Claim 10 (depends on 9) The method of claim 9, wherein identifying the plaque region further comprises outlining the plaque region in one of the ultrasound images. ### Claim 11 (depends on 9) The method of claim 9, further comprising forming an anatomical map of the plaque region which shows pixels wherein the perfusion has been identified. ### Claim 12 (depends on 9) The method of claim 9, further comprising quantifying the percentage of pixels in an image of the plaque region which exhibit the perfusion. ### Claim 13 (depends on 9) The method of claim 9, further comprising compensating for frame-to-frame motion in the sequence of ultrasound images. ### Claim 14 (depends on 9) The method of claim 9, further comprising correlating pixels in the image of the plaque region wherein the perfusion has been identified with pixels in the image of the plaque region wherein a motion is present. ### Claim 15 (depends on 9) The method of claim 9, further comprising forming a time intensity curve of the mean signal from within the plaque region to identify the arrival of the contrast in the plaque region. ### Claim 16 (depends on 1) The ultrasonic diagnostic imaging system of claim 1, wherein the second plurality of time intensity curves are formed after contrast arrival in the plaque region.