# US 10,479,865 B2 · Process for the preparation of sevelamer carbonate

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,479,865 B2
- Document ID: US10479865B2
- Status: Granted
- Kind: B2
- Application number: 15/903,510
- Filed: 2018-02-23
- Published: 2019-05-02
- Granted: 2019-11-19
- Earliest claimed: 2017-11-01
- Assignees: Strides Shasun Limited
- Applicants: Strides Shasun Limited
- Inventors: Narayanan Sivasankaran; Iyappan Murugan; Karikalan Thangaraju; Iyyanar Kuppusamy; Uttam Kumar Ray; Tangirala Vittal
- Web page: https://patentgrep.com/patent/US10479865B2

## CPC

- C08G 73/022: {from polyamines and epihalohydrins}
- B01J 13/0056: {containing inorganic material and water}
- B01J 13/0069: {Post treatment}
- C08J 3/075: Macromolecular gels
- B01J 2219/00177: controlling the pH
- C08G 2220/00: Compositions for preparing gels other than hydrogels, aerogels and xerogels
- C08J 2379/02: Polyamines
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- C08J: WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H (working, e.g. shaping, of plastics B29)

## Abstract

The present invention relates to a process for the preparation of Sevelamer carbonate from polyallylamine hydrochloride.

## Claims

### Claim 1

A process for the preparation of Sevelamer carbonate, comprising:
(a) contacting an aqueous alkaline solution of polyallylamine hydrochloride with epichlorohydrin at a pH of more than 12;
(b) maintaining the reaction mixture obtained in step (a) under stirring until the formation of gel;
(c) optionally washing the gel with at least one of water miscible solvent(s) and water;
(d) suspending the obtained gel in step (b) or step (c) in water;
(e) treating the suspension obtained in step (d) with carbon dioxide in water to obtain Sevelamer carbonate; and
(f) optionally washing the Sevelamer carbonate with at least one of water miscible solvent(s) and water.

### Claim 2 (depends on 1)

The process according to claim 1, wherein the aqueous alkaline solution of polyallylamine hydrochloride is prepared by dissolving the polyallylamine hydrochloride in water to obtain an aqueous solution of polyallylamine hydrochloride; the process further comprising treatment with a solution of alkali or alkaline earth metal hydroxides.

### Claim 3 (depends on 2)

The process according to claim 2, wherein the alkali or alkaline earth metal hydroxides is selected from the group comprising: sodium hydroxide, potassium hydroxide, calcium hydroxide, and magnesium hydroxide.

### Claim 4 (depends on 1)

The process according to claim 1, wherein the pH is in the range of 12 to 14.

### Claim 5 (depends on 1)

The process according to claim 1, wherein the pH is in the range of 13 to 14.

### Claim 6 (depends on 1)

The process according to claim 1, wherein the water miscible solvent in step (c) or step (f) is selected from the group comprising: C1-C4 alcohol, dimethylformamide, tetrahydrofuran, dimethyl sulfoxide, and acetonitrile.

### Claim 7 (depends on 6)

The process according to claim 6, wherein the water miscible solvent in step (c) comprises isopropanol.

### Claim 8 (depends on 6)

The process according to claim 6, wherein the water miscible solvent in step (f) comprises methanol.

### Claim 9

A process for the preparation of Sevelamer carbonate, comprising:
(a) contacting an aqueous alkaline solution of polyallylamine hydrochloride with epichlorohydrin at a pH in the range of 13 to 14;
(b) maintaining the reaction mixture obtained in step (a) under stirring until the formation of gel;
(c) optionally washing the gel with isopropanol and water;
(d) suspending the obtained gel in step (b) or step (c) in water;
(e) treating the suspension obtained in step (d) with carbon dioxide in water to obtain Sevelamer carbonate; and
(f) optionally washing the Sevelamer carbonate with methanol and water.

### Claim 10 (depends on 1)

The process according to any of the claim 1, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 11 (depends on 2)

The process according to any of the claim 2, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 12 (depends on 3)

The process according to any of the claim 3, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 13 (depends on 4)

The process according to any of the claim 4, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 14 (depends on 5)

The process according to any of the claim 5, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 15 (depends on 6)

The process according to any of the claim 6, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 16 (depends on 7)

The process according to any of the claim 7, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 17 (depends on 8)

The process according to any of the claim 8, wherein the reaction mixture in step (b) is maintained for about 30 minutes.

### Claim 18 (depends on 9)

The process according to any of the claim 9, wherein the reaction mixture in step (b) is maintained for about 30 minutes.