# US 10,478,563 B2 · Fluoropolymer barrier materials for containers

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- Number: US 10,478,563 B2
- Document ID: US10478563B2
- Status: Granted
- Kind: B2
- Application number: 15/425,075
- Filed: 2017-02-06
- Published: 2017-06-22
- Granted: 2019-11-19
- Earliest claimed: 2009-10-29
- Assignees: W. L. Gore & Associates, Inc.
- Applicants: W. L. Gore & Associates, Inc.
- Inventors: Edgar G. Ashmead; Edward C. Gunzel; Michael P. Moritz
- Web page: https://patentgrep.com/patent/US10478563B2

## CPC

- A61M 5/31513: {Piston constructions to improve sealing or sliding}
- A61J 1/1468: {Containers characterised by specific material properties}
- A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)}
- A61M 2005/3118: {via the distal end of a syringe, i.e. syringe end for mounting a needle cannula}
- A61M 2005/3131: {specially adapted for improving sealing or sliding}
- A61M 2207/00: Methods of manufacture, assembly or production
- Y10T 156/1043: Subsequent to assembly
- Y10T 428/1321: Polymer or resin containing [i.e., natural or synthetic]
- Y10T 428/1352: Polymer or resin containing [i.e., natural or synthetic]
- Y10T 428/1359: Three or more layers [continuous layer]
- Y10T 428/1376: Foam or porous material containing
- Y10T 428/24992: Density or compression of components
- Y10T 428/3154: Of fluorinated addition polymer from unsaturated monomers
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61J: CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

## Claims

### Claim 1

A syringe stopper for an unlubricated syringe, said syringe stopper comprising:
an elastomeric body comprising an elastomer; and
an expanded fluoropolymer positioned on said elastomeric body,
wherein said elastomer is at least partially imbibed into said expanded fluoropolymer.

### Claim 2 (depends on 1)

The syringe stopper of claim 1, wherein said expanded fluoropolymer is expanded polytetrafluoroethylene.

### Claim 3 (depends on 1)

The syringe stopper of claim 1, wherein said elastomeric body comprises a rubber selected from butyl, bromobutyl, chlorobutyl, silicone, nitrile, styrene butadiene, polychloroprene, ethylene propylene diene, fluoroelastomers or blends of any of the foregoing.

### Claim 4 (depends on 1)

The syringe stopper of claim 1, wherein said expanded fluoropolymer has a thickness from 0.5 microns to 20 microns.

### Claim 5 (depends on 1)

The syringe stopper, of claim 1, wherein said expanded fluoropolymer is pre-treated with at least one treatment selected from chemical etching, plasma treating, corona, and physical modification.

### Claim 6 (depends on 1)

The syringe stopper of claim 1, wherein said expanded fluoropolymer is post-treated with at least one treatment selected from chemical etching, plasma treating, corona, and physical modification.

### Claim 7 (depends on 1)

The syringe stopper of claim 1, further comprising at least one barrier polymer selected from polytetrafluoroethylene, densified expanded polytetrafluoroethylene, fluorinated ethylene propylene, polyethylene, polypropylene, polyvinylidene fluoride, polyvinylfluoride, perfluoropropylevinylether and perfluoroalkoxy polymer, wherein said at least one barrier polymer is positioned on said expanded fluoropolymer layer.

### Claim 8 (depends on 1)

A syringe comprising the syringe stopper of claim 1.

### Claim 9 (depends on 8)

The syringe of claim 8, wherein said syringe is free of lubricant.