# US 10,478,528 B2 · Bone graft implants containing allograft

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,478,528 B2
- Document ID: US10478528B2
- Status: Granted
- Kind: B2
- Application number: 15/200,801
- Filed: 2016-07-01
- Published: 2016-10-27
- Granted: 2019-11-19
- Earliest claimed: 2013-03-14
- Assignees: Prosidyan, Inc.
- Applicants: Prosidyan, Inc.
- Inventors: Charanpreet S. Bagga; Steven B. Jung; Hyun W. Bae
- Web page: https://patentgrep.com/patent/US10478528B2

## CPC

- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/12: Phosphorus-containing materials, e.g. apatite
- A61L 27/24: Collagen
- A61L 27/32: Phosphorus-containing materials, e.g. apatite
- A61L 27/34: Macromolecular materials
- A61L 27/3608: {Bone, e.g. demineralised bone matrix [DBM], bone powder}
- A61L 27/365: {Bones}
- A61L 27/425: {of phosphorus containing material, e.g. apatite}
- A61L 27/427: {of other specific inorganic materials not covered by A61L27/422 or A61L27/425}
- A61L 27/46: with phosphorus-containing inorganic fillers
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 2300/104: Silver, e.g. silver sulfadiazine
- A61L 2300/112: Phosphorus-containing compounds, e.g. phosphates, phosphonates
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L 2300/414: Growth factors
- A61L 2300/64: Animal cells
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.

## Claims

### Claim 1

A porous, composite bone graft implant comprising:
a first component comprising a bioactive glass material in the form of a plurality of bioactive glass clusters, each cluster comprising a matrix of randomly oriented bioactive glass fibers and bioactive glass granules, at least some of the fibers and granules being sintered together, the clusters further including a bioactive glass shell at least partially encasing the matrix;
a second component comprising an allograft material, the second component being interspersed with the first component throughout the composite bone graft implant; and
a third component comprising a polymeric coating extending over the implant;
wherein the composite implant comprises a pore size distribution including at least a nanoporosity, and wherein the composite implant is pliable.

### Claim 2 (depends on 1)

The implant of claim 1, wherein the coating comprises an organic acid.

### Claim 3 (depends on 1)

The implant of claim 1, wherein the coating comprises a mineralogical calcium source.

### Claim 4 (depends on 3)

The implant of claim 3, wherein the mineralogical calcium source is a calcium salt.

### Claim 5 (depends on 1)

The implant of claim 1, wherein the bioactive glass shell is porous.

### Claim 6 (depends on 1)

The implant of claim 1, wherein the bioactive glass fibers are porous.

### Claim 7 (depends on 1)

The implant of claim 1, wherein the bioactive glass granules are porous.

### Claim 8 (depends on 1)

The implant of claim 1, wherein the bioactive glass granules have varying sizes.

### Claim 9 (depends on 1)

The implant of claim 1, wherein the bioactive glass fibers have varying sizes.