# US 10,478,522 B2 · Biocompatible material in granules made of metal material or metal alloys and use of said granules for vertebroplasty

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- Number: US 10,478,522 B2
- Document ID: US10478522B2
- Status: Granted
- Kind: B2
- Application number: 15/327,248
- Filed: 2015-07-17
- Published: 2017-06-08
- Granted: 2019-11-19
- Earliest claimed: 2014-07-18
- Assignees: Mt Ortho S.R.L.
- Applicants: MT ORTHO S.r.l.
- Inventors: Natale Francaviglia; Gaetano Sorano; Roberto Drago
- Web page: https://patentgrep.com/patent/US10478522B2

## CPC

- A61L 27/06: Titanium or titanium alloys
- A61L 27/56: Porous materials, {e.g. foams or sponges}
- B01J 19/085: {Electron beams only}
- B01J 19/121: {Coherent waves, e.g. laser beams (lasers per se H01S3/00)}
- A61B 17/8855: {inflatable, e.g. kyphoplasty balloons}
- A61L 2400/18: Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
- A61L 2430/38: for reconstruction of the spine, vertebrae or intervertebral discs
- B01J 2219/0879: Solid
- B01J 2219/12: Processes employing electromagnetic waves
- C22C 14/00: Alloys based on titanium
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- C22C: ALLOYS (treatment of alloys C21D, C22F)

## Abstract

More specifically, granules made of biocompatible metal material, preferably osteoinductive metal, for use in vertebroplasty surgery, as well as the use of these granules for this purpose, are the object of the present invention.

## Claims

### Claim 1

A granule made of biocompatible metal material or alloys of said metal material, wherein said granule comprises a solid spherical structure with an outer diameter of between 3 and 4 millimeters, and an outer surface having a trabeculated porous structure, wherein the trabeculated pores of the outer surface have a diameter of between 400 and 800 microns.

### Claim 2 (depends on 1)

The granule according to claim 1, wherein the pore diameter is about 600 microns.

### Claim 3 (depends on 1)

The granule according to claim 1, wherein said granule is made of titanium or titanium alloys.

### Claim 4 (depends on 1)

The granule according to claim 1, wherein said granule is made by means of production techniques that provide for at least one step of localized micro-fusion of powders through high energy electron beams (EBM) or laser.

### Claim 5 (depends on 1)

The granule according to claim 1, wherein said granule has an average size of smaller than 7 mm.

### Claim 6 (depends on 1)

The granule according to claim 1, wherein said granule comprises a connecting means for connecting said granule to at least another granule.

### Claim 7 (depends on 6)

Two or more granules of claim 6 connected together to form a chain of granules.

### Claim 8 (depends on 1)

The granule according to claim 1, wherein the pore diameter is 640 microns.

### Claim 9 (depends on 1)

The granule according to claim 1, wherein said granule is between 1 and 6 mm in size.

### Claim 10 (depends on 1)

The granule according to claim 1, wherein said granule is between 4 and 6 mm in size.

### Claim 11 (depends on 1)

The granule according to claim 1, wherein said granule has an outer diameter of about 3 millimeters.

### Claim 12 (depends on 1)

The granule according to claim 1, wherein said granule has an outer diameter of 3.3 millimeters.

### Claim 13 (depends on 1)

A method of performing a vertebroplasty surgery, said method comprising:
selecting a subject in need of vertebroplasty surgery;
providing a composition comprising a plurality of the granules of claim 1; and
depositing said composition into an internal cavity of one or more vertebra of the selected subject.