# US 10,478,520 B2 · Use of self-assembling polypeptides as tissue adhesives

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- Number: US 10,478,520 B2
- Document ID: US10478520B2
- Status: Granted
- Kind: B2
- Application number: 14/422,170
- Filed: 2013-08-14
- Published: 2015-11-19
- Granted: 2019-11-19
- Earliest claimed: 2012-08-17
- Assignees: Amsilk GmbH
- Applicants: AMSilk GmbH
- Inventors: Axel Leimer; Lin Römer; Nathalie Maksimovikj
- Web page: https://patentgrep.com/patent/US10478520B2

## CPC

- A61L 24/10: Polypeptides; Proteins {(A61L24/043 takes precedence)}
- A61F 2/02: Prostheses implantable into the body
- A61F 2/12: Mammary prostheses
- A61L 24/102: {Collagen}
- A61L 24/108: {Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106}
- A61L 27/34: Macromolecular materials
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61F 2210/00: Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F 2210/0076: multilayered, e.g. laminated structures
- A61L 26/0047: {Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042}
- A61L 31/047: {Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046}
- A61L 2300/252: Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L 2300/606: Coatings
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

The present invention relates to a self-assembling polypeptide for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.

## Claims

### Claim 1

An implant uniformly coated with a spider silk polypeptide by dipping or immersing the implant into a liquid composition consisting essentially of the spider silk polypeptide and a solvent or by spraying a liquid aerosol consisting essentially of the spider silk polypeptide and a solvent onto the implant, before subsequently drying the implant.

### Claim 2 (depends on 1)

The implant of claim 1, wherein the implant is a soft tissue implant.

### Claim 3 (depends on 2)

The implant of claim 2, wherein the soft tissue implant is a silicone implant or an implant with a silicone surface.

### Claim 4 (depends on 1)

The implant of claim 1, wherein the silk polypeptide is a recombinant silk polypeptide.

### Claim 5

A method for uniformly coating an implant with a spider silk polypeptide comprising the step of dipping or immersing the implant into a liquid composition consisting essentially of the spider polypeptide and a solvent, or spraying a liquid aerosol consisting essentially of the spider polypeptide and a solvent onto the implant, before subsequently drying the implant, thereby uniformly coating the implant.

### Claim 6 (depends on 2)

The implant of claim 2, wherein the soft tissue implant is a breast implant.

### Claim 7

An implant uniformly coated with a spider silk polypeptide film by dipping or immersing the implant into a liquid composition consisting essentially of the spider silk polypeptide and a solvent or by spraying a liquid aerosol consisting essentially of the spider silk polypeptide and a solvent onto the implant, before subsequently drying the implant.

### Claim 8 (depends on 5)

An implant coated with a spider silk polypeptide film by the method of claim 5.